An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research

用于脂质组学研究的超高分辨率质谱仪： 这项提议旨在澳大利亚建立一个超高分辨率、准确的质谱学设施，用于全面的脂质组学研究。该平台将由一个热科学轨道聚变质谱仪和超高压高效液相色谱接口组成。这项建议将满足哺乳动物、植物、寄生虫和微藻研究领域对基于高级质谱学的脂肪分析能力的主要需求，并使脂类分离、化学和反应性的基础研究成为可能。该仪器将适用于各种项目，包括研究脂代谢在哺乳动物生物化学和细胞生物学、植物生物学和寄生虫学中的作用，以及微藻生物燃料生产。

An ultra-high-resolution mass spectrometry facility for lipidomics research: This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.