Promoting renoprotection by unravelling the roles of renal oxygenation, energy metabolism and inflammation by physiometabolic magnetic resonance (B04)

目前针对急性肾损伤(AKI)和慢性肾脏疾病(CKD)的治疗方法很少，因为AKI的病理生理学和进展为CKD的复杂性。肾组织低灌注、低氧、高能代谢改变与炎症密切相关。在这个项目中，我们将研究低灌流、低氧、能量代谢和炎症在不同来源的AKI中的作用和因果关系。这些过程将通过综合多模式方法(MR-PhysIOL-NIRS)进行检查：磁共振(1H、19F、31P MR)、生理读数(PhysIOL)和近红外光谱(NIRS)。我们的方法在啮齿类动物的生理代谢MR与导致临床研究的翻译研究之间架起了桥梁。

Current treatments targeting acute kidney injury (AKI) and chronic kidney disease (CKD) are sparse due to the complexity of AKI pathophysiology and its progression to CKD. Renal tissue hypoperfusion, hypoxia, altered high energy metabolism and inflammation are tightly entangled. In this project, we will study the contributions and cause-effect relationships of hypoperfusion, hypoxia, energy metabolism and inflammation in AKI of various origins. These processes will be examined with an integrated multi-modality approach (MR-PHYSIOL-NIRS): magnetic resonance (1H, 19F, 31P MR), physiological readouts (PHYSIOL) and near infrared spectroscopy (NIRS). Our approach bridges physiometabolic MR in rodents with translational research leading to clinical studies.