Promoting renoprotection by unravelling the roles of renal oxygenation, energy metabolism and inflammation by physiometabolic magnetic resonance (B04)

通过生理代谢磁共振揭示肾脏氧合、能量代谢和炎症的作用，促进肾脏保护 (B04)

• 批准号: 418380391
• 金额: --
• 依托单位: Forschungsgruppe Experimentelle Ultrahochfeld-MR
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418380391?language=en
• 关键词: Promoting; renoprotection; unravelling; roles; renal

Current treatments targeting acute kidney injury (AKI) and chronic kidney disease (CKD) are sparse due to the complexity of AKI pathophysiology and its progression to CKD. Renal tissue hypoperfusion, hypoxia, altered high energy metabolism and inflammation are tightly entangled. In this project, we will study the contributions and cause-effect relationships of hypoperfusion, hypoxia, energy metabolism and inflammation in AKI of various origins. These processes will be examined with an integrated multi-modality approach (MR-PHYSIOL-NIRS): magnetic resonance (1H, 19F, 31P MR), physiological readouts (PHYSIOL) and near infrared spectroscopy (NIRS). Our approach bridges physiometabolic MR in rodents with translational research leading to clinical studies.

由于阿基病理生理学的复杂性及其向CKD的进展，目前靶向急性肾损伤（阿基）和慢性肾病（CKD）的治疗很少。肾组织灌注不足、缺氧、高能代谢改变和炎症密切相关。在本研究中，我们将研究低灌注、缺氧、能量代谢和炎症在各种原因的阿基中的作用和因果关系。这些过程将采用综合多模态方法（MR-PHYSIOL-NIRS）进行检查：磁共振（1H、19 F、31 P MR）、生理读数（PHYSIOL）和近红外光谱（NIRS）。我们的方法将啮齿类动物的生理代谢MR与转化研究联系起来，从而进行临床研究。