Controllable dissolution of sol-gel derived borate glasses for accelerating wound healing

溶胶-凝胶衍生硼酸盐玻璃的可控溶解加速伤口愈合

• 批准号: 419186269
• 负责人: Professor Dr.-Ing. Aldo Boccaccini
• 金额: --
• 依托单位: Lehrstuhl Biomaterialien
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/419186269?language=en
• 关键词: Controllable; dissolution; sol; gel; derived

Borate bioactive glasses (borate BGs) have shown impressive healing effects on chronic wounds clinically. Their dissolution behavior, in terms of the release profile of ionic dissolution products and dissolution rate, determines wound healing effects. A well-controlled dissolution behavior of borate BGs can accelerate wound healing. However, there has been no previous comprehensive study aiming at establishing the relationship between the dissolution behavior of borate BGs and wound healing effects.The final objective of this research project is to achieve accelerated wound healing by controlling the dissolution behavior of sol-gel derived borate BG through tuning glass compositions. The relationship between glass composition and wound healing effects, which is of paramount importance to be able to elucidate the mechanisms involved of borate BGs healing wounds, indeed the dissolution behavior of borate BGs, will be investigated and established in this project. Specifically, a series of B2O3-CaO-CuO borate glasses, considering the composition containing biologically active ions Ca2+ (hemostatic activity), B3+ (angiogenic activity), and Cu2+ (antibacterial and angiogenic activities), will be synthesized and characterized. Sol-gel based approaches will be used to synthesize borate BGs, given the better control in the morphology of synthesized BGs in the sol-gel approaches. Since the dissolution behavior (dissolution rates, ion release) of borate glasses is closely related to their composition and structure, it is expected to be able to tune and control glass dissolution behavior by tailoring the composition. To achieve the understanding of the compositional dependence of the complex wound healing process, the effects of the dissolution products of the glasses on the biological activities related to wound healing, i.e., hemostatic activity, antibacterial effect, and angiogenic potential, will be evaluated.By completing the project, accelerated wound healing effects are expected to be achieved by controlling the glass’s dissolution behavior. A deeper understanding of the composition-dissolution behavior relationship in borate BGs will be gained from the experimental program of this project. Such understanding will contribute to elucidating the mechanisms underlying the effects of borate BGs on wound healing. The development of sol-gel methods for producing borate BGs will be beneficial for developing advanced wound healing dressing, considering a better control in morphology and composition of BGs in the sol-gel approaches.

硼酸盐生物活性玻璃（硼酸盐BG）在临床上对慢性伤口显示出令人印象深刻的愈合效果。它们的溶解行为，就离子溶解产物的释放曲线和溶解速率而言，决定了伤口愈合效果。硼酸盐 BG 良好控制的溶解行为可以加速伤口愈合。然而，之前还没有旨在建立硼酸盐BG的溶解行为与伤口愈合效果之间关系的综合研究。该研究项目的最终目标是通过调整玻璃成分来控制溶胶-凝胶衍生的硼酸盐BG的溶解行为，从而实现加速伤口愈合。本项目将研究和建立玻璃成分与伤口愈合效果之间的关系，这对于阐明硼酸盐 BG 愈合伤口的机制（实际上是硼酸盐 BG 的溶解行为）至关重要。具体来说，将合成并表征一系列B2O3-CaO-CuO硼酸盐玻璃，考虑到含有生物活性离子Ca2+（止血活性）、B3+（血管生成活性）和Cu2+（抗菌和血管生成活性）的成分。基于溶胶-凝胶的方法将用于合成硼酸盐 BG，因为溶胶-凝胶方法可以更好地控制合成的 BG 的形态。由于硼酸盐玻璃的溶解行为（溶解速率、离子释放）与其成分和结构密切相关，因此期望能够通过调整成分来调整和控制玻璃溶解行为。为了了解复杂的伤口愈合过程的成分依赖性，将评估玻璃的溶解产物对与伤口愈合相关的生物活性（即止血活性、抗菌作用和血管生成潜力）的影响。通过完成该项目，预计将通过控制玻璃的溶解行为来实现加速伤口愈合的效果。通过本项目的实验计划，可以更深入地了解硼酸盐 BG 中的成分-溶解行为关系。这种理解将有助于阐明硼酸盐 BG 对伤口愈合影响的机制。考虑到在溶胶-凝胶方法中更好地控制 BG 的形态和组成，用于生产硼酸盐 BG 的溶胶-凝胶方法的发展将有利于开发先进的伤口愈合敷料。