Controllable dissolution of sol-gel derived borate glasses for accelerating wound healing

硼酸盐生物活性眼镜（Borate BGs）在慢性伤口的临床治疗中显示出令人印象深刻的愈合效果。它们的溶解行为，即离子溶解产物的释放谱和溶解速率，决定了伤口愈合的效果。良好控制硼酸盐BGs的溶解行为可以加速伤口愈合。然而，目前还没有全面的研究旨在建立硼酸盐BGs的溶解行为与伤口愈合效果的关系。本研究项目的最终目标是通过调整玻璃成分来控制溶胶-凝胶衍生硼酸BG的溶解行为，从而加速伤口愈合。该项目将研究和建立玻璃成分与伤口愈合效果之间的关系，这对于阐明硼酸钡愈合伤口的机制以及硼酸钡的溶解行为至关重要。具体而言，将合成并表征一系列B2O3-CaO-CuO硼酸盐玻璃，考虑其组成中含有生物活性离子Ca2+（止血活性），B3+（血管生成活性）和Cu2+（抗菌和血管生成活性）。由于溶胶-凝胶法能更好地控制合成硼酸钡的形态，因此将采用溶胶-凝胶法合成硼酸钡。由于硼酸盐玻璃的溶解行为（溶解速率、离子释放）与其组成和结构密切相关，因此有望通过调整组成来调节和控制玻璃的溶解行为。为了了解复杂伤口愈合过程的成分依赖性，将评估玻璃溶解产物对伤口愈合相关生物活性的影响，即止血活性、抗菌作用和血管生成潜力。通过完成该项目，通过控制玻璃的溶解行为，有望实现加速伤口愈合的效果。本项目的实验方案将对硼酸盐BGs的组成-溶解行为关系有更深入的了解。这样的理解将有助于阐明硼酸盐BGs对伤口愈合的影响机制。溶胶-凝胶法制备硼酸硼酸凝胶，可以更好地控制硼酸硼酸凝胶的形态和组成，有利于开发先进的伤口愈合敷料。

Borate bioactive glasses (borate BGs) have shown impressive healing effects on chronic wounds clinically. Their dissolution behavior, in terms of the release profile of ionic dissolution products and dissolution rate, determines wound healing effects. A well-controlled dissolution behavior of borate BGs can accelerate wound healing. However, there has been no previous comprehensive study aiming at establishing the relationship between the dissolution behavior of borate BGs and wound healing effects.The final objective of this research project is to achieve accelerated wound healing by controlling the dissolution behavior of sol-gel derived borate BG through tuning glass compositions. The relationship between glass composition and wound healing effects, which is of paramount importance to be able to elucidate the mechanisms involved of borate BGs healing wounds, indeed the dissolution behavior of borate BGs, will be investigated and established in this project. Specifically, a series of B2O3-CaO-CuO borate glasses, considering the composition containing biologically active ions Ca2+ (hemostatic activity), B3+ (angiogenic activity), and Cu2+ (antibacterial and angiogenic activities), will be synthesized and characterized. Sol-gel based approaches will be used to synthesize borate BGs, given the better control in the morphology of synthesized BGs in the sol-gel approaches. Since the dissolution behavior (dissolution rates, ion release) of borate glasses is closely related to their composition and structure, it is expected to be able to tune and control glass dissolution behavior by tailoring the composition. To achieve the understanding of the compositional dependence of the complex wound healing process, the effects of the dissolution products of the glasses on the biological activities related to wound healing, i.e., hemostatic activity, antibacterial effect, and angiogenic potential, will be evaluated.By completing the project, accelerated wound healing effects are expected to be achieved by controlling the glass’s dissolution behavior. A deeper understanding of the composition-dissolution behavior relationship in borate BGs will be gained from the experimental program of this project. Such understanding will contribute to elucidating the mechanisms underlying the effects of borate BGs on wound healing. The development of sol-gel methods for producing borate BGs will be beneficial for developing advanced wound healing dressing, considering a better control in morphology and composition of BGs in the sol-gel approaches.