400 MHz NMR-Konsole

为了满足由于“Beiblätter zur Forschung”中描述的项目（其中包括LOEWE中心DRUID内的其他项目）而增加的NMR光谱学要求，应购买光谱仪控制台、灵敏的多芯探头和大容量进样器。新的收购不仅增加了样品容量，而且特别是能够测量浓度非常低的样品，扩展异核测量以及通过19F NMR光谱测定蛋白质动力学。这些研究项目的目的包括开发防治被忽视的热带疾病（如血吸虫病）、寄生虫病、高致病性病毒和细菌的活性物质，以及设计和合成甲基转移酶、丝氨酸蛋白酶、纤溶酶和间质蛋白酶的选择性抑制剂。进一步的目标是表征热力学和结合动力学参数的酶，以及在配体结合过程中的构型重排的测定。此外，生物传感器的发展，含硫的次生代谢产物的葱属的鉴定，以及发现真菌的生物合成潜力和调查他们的次生代谢。

In order to meet the increased requirements on the nmr spectroscopy due to the projects described in ´Beiblätter zur Forschung´ (amongst others within the LOEWE center DRUID), a spectrometer console, a sensitive multicore probe head and a high-capacity sample changer shall be purchased. The new acquisition will not only increase the sample capacity but in particular enable the measurement of samples with very low concentration, the expansion of measurements of hetero nuclei as well as the determination of protein dynamics by means of 19F nmr spectroscopy. The aims of the research projects comprise the development of active substances against neglected tropical diseases (e.g.schistosomiasis), parasitic diseases, highly pathogenic viruses and bacteria, as well as design and synthesis of selective inhibitors of methyl transferase, serine proteases, of plasmin and matriptase. Further aims are the characterization of thermodynamic and binding kinetic parameters of enzymes as well as the determination of the rearrangement of configuration during ligand binding. Furthermore, the development of biosensors, the identification of sulfur-containing secondary metabolites of the genus Allium, as well as the discovery of the biosynthetic potential of fungi and the investigation of their secondary metabolisms are pursued.