Functional proteomics dissection of chemotactic protein diversity (A13*)

趋化蛋白多样性的功能蛋白质组学剖析 (A13*)

• 批准号: 426908965
• 金额: --
• 依托单位: Institut für Angeborene Immunität
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426908965?language=en
• 关键词: Functional; proteomics; dissection; chemotactic; protein

Chemotactic protein activity is regulated at multiple levels, including post-translational modifications. In this project, we will test the hypothesis that divergent paracrine activities arise from differentially modified chemotactic protein variants (proteoforms) by combining proteomics discovery technologies, systems biology and functional validation approaches. Thereby, we will establish a system-level view of chemokine proteoform diversity and will generate new insights about how paracrine signals and their modifications affect cell signaling and chemotaxis during tissue homeostasis and inflammation.

趋化蛋白活性在多个水平上受到调节，包括翻译后修饰。在这个项目中，我们将通过结合蛋白质组学发现技术，系统生物学和功能验证方法来测试不同的旁分泌活动产生于差异修饰的趋化蛋白变体（proteoforms）的假设。因此，我们将建立一个系统水平的观点，趋化因子蛋白质的多样性，并将产生新的见解旁分泌信号及其修饰如何影响细胞信号和趋化性在组织稳态和炎症。