Functional proteomics dissection of phagocyte derived signals during CNS inflammation and recovery (A07)

中枢神经系统炎症和恢复过程中吞噬细胞衍生信号的功能蛋白质组学解析（A07）

• 批准号: 434449843
• 金额: --
• 依托单位: Institut für Angeborene Immunität
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/434449843?language=en
• 关键词: Functional; proteomics; dissection; phagocyte; derived

Communication between phagocytes, glia and neurons regulates homeostasis in the CNS. Due to technical limitations in studying intercellular signals thoroughly, it is still unclear how phagocyte derived signals can induce the formation of destructive tissue inflammation, while signals from the same cells promote the resolution of inflammation and subsequent tissue repair. We aim to develop advanced mass spectrometry-based proteomics tools to dissect signals exchanged between phagocytes and CNS resident cells, to identify shared molecular checkpoints of neuro-recovery across mouse models of toxic and inflammatory injury.

吞噬细胞、神经胶质细胞和神经元之间的通讯调节中枢神经系统的稳态。由于彻底研究细胞间信号的技术限制，目前尚不清楚吞噬细胞衍生的信号如何诱导破坏性组织炎症的形成，而来自相同细胞的信号促进炎症的消退和随后的组织修复。我们的目标是开发先进的基于质谱的蛋白质组学工具来剖析吞噬细胞和CNS驻留细胞之间交换的信号，以确定毒性和炎症损伤小鼠模型中神经恢复的共同分子检查点。