Functional proteomics dissection of phagocyte derived signals during CNS inflammation and recovery (A07)

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Communication between phagocytes, glia and neurons regulates homeostasis in the CNS. Due to technical limitations in studying intercellular signals thoroughly, it is still unclear how phagocyte derived signals can induce the formation of destructive tissue inflammation, while signals from the same cells promote the resolution of inflammation and subsequent tissue repair. We aim to develop advanced mass spectrometry-based proteomics tools to dissect signals exchanged between phagocytes and CNS resident cells, to identify shared molecular checkpoints of neuro-recovery across mouse models of toxic and inflammatory injury.