Coordination Funds

协调基金

• 批准号: 428358807
• 负责人: Professor Dr. Florian R. Greten
• 金额: --
• 依托单位: Georg-Speyer-Haus, Institut für Tumorbiologie und experimentelle Therapie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/428358807?language=en
• 关键词: Coordination; Funds

For the development of colorectal cancer (CRC) cell-autonomous events alone are insufficient. Accumulating epidemiological, genetic and preclinical experimental evidence strongly indicate that the cytokine milieu in the tumor microenvironment plays a decisive role at all stages of CRC development as well as during cytotoxic therapy. Cytokines and other signal proteins control the plasticity of stromal, tumor and cancer stem like cells in an autocrine and paracrine manner thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this Research Unit aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. The consortium will create a unique network bringing together leading basic and clinical scientists with complementary expertise in the fields of gastroenterology, immunology, pathology, surgery, molecular biology, cell biology and tumor biology that have one common goal: the development and preclinical assessment of novel strategies for prevention and therapy of CRC based on interference with cell plasticity in the tumor micro-environment. This powerful interdisciplinary network of clinical and basic scientists with a translational research focus that unify their expertise on a common topic will set the basis for the development of innovative therapeutic approaches that will go clearly beyond the current standard of care.

对于结直肠癌（CRC）的发展，仅靠细胞自主事件是不够的。越来越多的流行病学、遗传学和临床前实验证据强烈表明，肿瘤微环境中的细胞因子环境在结直肠癌发展的各个阶段以及细胞毒性治疗过程中起着决定性作用。细胞因子和其他信号蛋白以自分泌和旁分泌的方式控制基质、肿瘤和癌干细胞样细胞的可塑性，从而形成复杂的细胞环境，最终形成促或抗肿瘤环境。因此，本研究单元旨在收集对基质细胞和肿瘤/干细胞可塑性负责的介质依赖性细胞和分子事件的全面功能理解。该联盟将创建一个独特的网络，汇集领先的基础和临床科学家，他们在胃肠病学、免疫学、病理学、外科、分子生物学、细胞生物学和肿瘤生物学领域具有互补的专业知识，他们有一个共同的目标：基于肿瘤微环境中细胞可塑性的干扰，开发和临床前评估预防和治疗结直肠癌的新策略。这个强大的跨学科网络由临床和基础科学家组成，以转化研究为重点，将他们的专业知识统一在一个共同的主题上，将为创新治疗方法的发展奠定基础，这将明显超越当前的护理标准。