Coordination Funds

对于结直肠癌（CRC）的发展，单独的细胞自主事件是不够的。累积的流行病学、遗传学和临床前实验证据强烈表明，肿瘤微环境中的细胞因子环境在CRC发展的所有阶段以及细胞毒性治疗期间起决定性作用。细胞因子和其他信号蛋白以自分泌和旁分泌方式控制基质、肿瘤和癌症干细胞样细胞的可塑性，从而形成复杂的细胞结构，其最终形成促肿瘤发生或抗肿瘤发生的环境。因此，该研究单位的目的是收集一个全面的功能理解介导依赖的细胞和分子事件，负责基质和肿瘤/干细胞的可塑性。该联盟将创建一个独特的网络，汇集领先的基础和临床科学家，他们在胃肠病学，免疫学，病理学，外科手术，分子生物学，细胞生物学和肿瘤生物学领域具有互补的专业知识，这些领域有一个共同的目标：开发和临床前评估基于干扰肿瘤微环境中细胞可塑性的CRC预防和治疗新策略。这个强大的跨学科网络的临床和基础科学家与转化研究的重点，统一他们的专业知识在一个共同的主题将为创新的治疗方法，将明显超越目前的护理标准的发展奠定基础。

For the development of colorectal cancer (CRC) cell-autonomous events alone are insufficient. Accumulating epidemiological, genetic and preclinical experimental evidence strongly indicate that the cytokine milieu in the tumor microenvironment plays a decisive role at all stages of CRC development as well as during cytotoxic therapy. Cytokines and other signal proteins control the plasticity of stromal, tumor and cancer stem like cells in an autocrine and paracrine manner thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this Research Unit aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. The consortium will create a unique network bringing together leading basic and clinical scientists with complementary expertise in the fields of gastroenterology, immunology, pathology, surgery, molecular biology, cell biology and tumor biology that have one common goal: the development and preclinical assessment of novel strategies for prevention and therapy of CRC based on interference with cell plasticity in the tumor micro-environment. This powerful interdisciplinary network of clinical and basic scientists with a translational research focus that unify their expertise on a common topic will set the basis for the development of innovative therapeutic approaches that will go clearly beyond the current standard of care.