High-Pressure Liquid Chromatography Triple Quadrupole Mass Spectrometer with highest sensitivity (HPLC-MS/MS)

最高灵敏度的高压液相色谱三重四极杆质谱仪 (HPLC-MS/MS)

• 批准号: 428824233
• 金额: --
• 依托单位: Justus-Liebig-Universität Gießen
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/428824233?language=en
• 关键词: Pressure; Liquid; Chromatography; Triple; Quadrupole

The HPLC-MS/MS system extends the spectrum of trace compounds that can be detected complementary to the extraction methods established at the Institute of Soil Science and Soil Conservation (Pressurized liquid extraction, ultrasonic extraction, microwave-assisted extraction). In this context the MS/MS detection is essential for ensuring reliable quantification in complex matrices, as well as for targeted screenings for metabolites and “emerging pollutants”. This strength of the triple-quad MS technique is also important in the fields of chemical food analysis, e.g. for the quantification of residue concentrations, and of interest in the field of insect biotechnology for research addressing the production and application of natural chemical compounds.With the appointment of Prof. Jan Siemens as Professor of Soil Resources the Institute of Soil Science and Soil Conservation strengthens it research focus regarding the fate of pollutants (esp. pharmaceuticals) in soils. Therefore, the trace analysis of polar pollutants in soils and related environmental compartments is currently extended. Due to the large degree of capacity utilization of HPLC-MS/MS instruments at the iFZ and neighboring institutes, this application for a versatile device with a combination of MS/MS interface and photodiode array detector for the sensitive quantification of trace concentrations of polar organic compounds is supported insistently also by other working groups.

HPLC-MS/MS系统扩展了痕量化合物的光谱，可以检测到土壤科学和土壤保持研究所建立的提取方法（加压液体提取，超声波提取，微波辅助提取）的补充。在这种情况下，MS/MS检测对于确保复杂基质中的可靠定量以及代谢物和“新兴污染物”的靶向筛选至关重要。三重四极质谱技术的这种优势在化学食品分析领域也很重要，例如用于残留物浓度的定量，随着Jan Siemens教授被任命为土壤资源教授，土壤科学与土壤保持研究所加强了其研究重点，关于污染物（特别是药物）在土壤中的命运。因此，目前正在扩大土壤和相关环境分区中极性污染物的痕量分析。由于iFZ和邻近研究所的HPLC-MS/MS仪器的容量利用率很高，因此其他工作组也支持将MS/MS接口和光电二极管阵列检测器相结合的多功能设备用于极性有机化合物痕量浓度的灵敏定量。