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Establishment of Pig Family of Congenital Diaphragmatic Hernia, and Studies on its Embryological Basis.

先天性膈疝猪家系的建立及其胚胎学基础研究。

基本信息

批准号：
01480304
负责人：
OHKAWA Haruo
金额：
$ 3.52万
依托单位：
Institute of Clinical Medicine, Tsukuda University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

Neonatal diaphragmatic hernia is one of the most improtant emergency diseases, with great difficulty of treatment and poor prognosis even in the present stage of pediatric Surgery. This study was performed with a final goal of improvement of the clinical results. Substantially this consists of a part of our research of a pig model with anorectal malformations, which has been established in our Unit.The main purpose of this study is to establish a pig family of congenital diaphragmatic hernia, from our pig Family with anorectal malformations. So the proper maintenance of our pig Family with anorectal malformations itself will be proven to be a great fruit of the present study.Unfortunately we did not obtain any new abnormal piglets after the first 13 pigs with congenital diaphragmatic hernia, and the operatively rescued female pig did not give any birth of anomalous piglets in the three normal deliveries. We have not succeeded in the production of Pig Family of congenital diaphragmatic hernia so far.Detailed anatomical and pathological studies on the 13 anomalous pigs with late onset were performed and were reported precisely in the J. Jpn. Soc. Pediatr. Surg. 1990. The heredity in the pig Family was analyzed by the statistical calculation and the autosomal double recessive genes were proven to exist. This results will be presented in the International Meeting of Pediatric Surgery this year, and will be pressed in the J. Pediatr. Surg.As without any fetus material with diaphragmatic hernia in this experiment up to the present, we have not been successful in the embryological analysis with anomalous materials so far.

新生儿横隔疝是最重要的急诊疾病之一，即使在现阶段的儿科手术中，治疗难度也很大，预后也很差。这项研究的最终目标是改善临床结果。这基本上是我们在本单位建立的猪肛门直肠畸形模型研究的一部分。本研究的主要目的是从我们的直肠肛门畸形猪家系中建立一个先天性横隔疝的猪家系。因此，正确维护我们的直肠肛门畸形猪家族本身将被证明是本研究的一大成果。不幸的是，我们在第一批13头先天性膈疝后没有获得任何新的异常仔猪，而手术抢救的母猪在三次正常分娩中也没有生下任何异常仔猪。到目前为止，我们还没有成功地制作出猪家系先天性隔疝。对13头发病较晚的异常猪进行了详细的解剖和病理研究，并在《J.Jpn》杂志上进行了准确的报道。SoC。佩迪亚特。外科手术，1990年。对该家猪的遗传进行了统计分析，证实了常染色体双隐性基因的存在。这一结果将在今年的国际儿科外科学会议上公布，并将在《儿科杂志》上发表。手术：到目前为止，由于本实验中没有任何合并横隔疝的胎儿材料，我们还没有成功地对异常材料进行胚胎学分析。