权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Hyper-running activity originating from the hypothalamus : An element of instinctive behaviors

源自下丘脑的超跑活动：本能行为的一个要素

基本信息

批准号：
02454099
负责人：
TAKAHASHI Michio
金额：
$ 4.42万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454099/
关键词：
Instinctive behavior Running activity VMH Polymer-gel GABA Kainate Glucose metabolism Circadian rhythm

项目摘要

We found that excitation of neurons in the ventromedial nucleus of the hypothalamus(VNM)induced stereotyped hyper-running, which was not associated with the motivation of an attack or escape. Such running activity is regarded as one of the principal elements of instinctive behaviors. Then it is presumed that stereotyped metabolic changes accompany the running activity. In this study, neurnal mechanisms in the VMH involved in inducing the hyper-running and in changing glucose metabolism were investigated.The injection of polymer-gel into the VMH was shown to induce the hyper-running. This was probably due to disinhibition of the GABAergic inhibitory neuronal system, since inclusion of GABA in the gel failed to induce the running activity. Injection of kainate into the VMH also induced the hyper-running ; the effect of kainate was not blocked by GABA. These findings suggest that neuroexcitatory amino acids acting at the kainate receptor in the VMH play a physiological role in inducing Junning activity and that the release of such amino acids are presynaptically inhibited by GABAergic neurons.Injection of kainate into the VMH increased plasma levels of corticosterone, epinephrine, norepinephrine and glucose, as well as inducing the hyper-running. This suggests that kainate receptors in the VMH are also involved in evoking metabolic changes required to maintain running activity.It is also suggested in the present study that the neuronal pathway via the marmmillary body and the midbrain central gray is involved in the VMH-inducing running activity and that neuronal output from the VMH affects the circadian locomotor activity.

我们发现，下丘脑腹内侧核（VNM）神经元的兴奋诱导刻板的超跑，这是不相关的攻击或逃跑的动机。这种跑步活动被认为是本能行为的主要因素之一。因此，可以推测，跑步活动伴随着刻板的代谢变化。本研究探讨了VMH中参与诱导超跑和改变糖代谢的神经机制，并证实了向VMH中注射聚合物凝胶可以诱导超跑。这可能是由于GABA能抑制性神经元系统的去抑制，因为在凝胶中包含GABA不能诱导运行活动。VMH内注射红藻氨酸也可引起运动过度，其作用不被GABA阻断。这些结果表明，作用于VMH红藻氨酸受体的神经兴奋性氨基酸在诱导Junning活动中起生理作用，并且这些氨基酸的释放被GABA能神经元突触前抑制。VMH注射红藻氨酸可增加血浆皮质酮、肾上腺素、去甲肾上腺素和葡萄糖的水平，并诱导过度运动。这表明VMH中的红藻氨酸受体也参与了维持跑步活动所需的代谢变化，本研究还表明，通过海马体和中脑中央灰质的神经元通路参与了VMH诱导的跑步活动，VMH的神经元输出影响了昼夜运动活动。