Rapid screening of gene(s) related to the phenotype of model rats with high levels of voluntarily wheel running activity
高水平自主轮跑活动模型大鼠表型相关基因的快速筛选
基本信息
- 批准号:23650406
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to identify gene(s) and molecular pathway(s) possibly related to the phenotype of model rats with high levels of voluntarily wheel running activity(Spontaneously-Running-Tokushima-Shikoku, SPORTS) established from Wistar rats, we established a novel integrated screening system through combining exome sequencing using a next-generation sequencer, linkage analysis, and selection algorithm using genome and polymorphism databases. Through this study, we successfully established a novel screening system for rat genome analysis and identified a set of candidate genes related to the phenotype of SPORTS rats.
为了鉴定可能与Wistar大鼠高水平自主轮跑活动模型(自发跑步-德岛四国,SPORTS)表型相关的基因和分子通路,我们建立了一种新的整合筛选系统,该系统将使用下一代测序仪的外显子组测序、连锁分析和使用基因组和多态性数据库的选择算法相结合。通过本研究,我们成功地建立了一个新的大鼠基因组分析筛选系统,并确定了一组与SPORTS大鼠表型相关的候选基因。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
メディカルサイエンス遺伝子検査学(IV染色体検査法-1染色体分染法-2染色法)
医学基因检测(IV染色体检测法-1染色体分割法-2染色法)
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Uesugi A;et al;井本逸勢
- 通讯作者:井本逸勢
miR-152 Is a Tumor Suppressor microRNA That Is Silenced by DNA Hypermethylation in Endometrial Cancer
- DOI:10.1158/0008-5472.can-11-0364
- 发表时间:2011-10-15
- 期刊:
- 影响因子:11.2
- 作者:Tsuruta, Tomohiko;Kozaki, Ken-ichi;Inazawa, Johji
- 通讯作者:Inazawa, Johji
HECT-type Ubiquitin Ligase ITCH Targets Lysosomal-associated Protein Multispanning Transmembrane 5 (LAPTM5) and Prevents LAPTM5-mediated Cell Death
- DOI:10.1074/jbc.m111.251694
- 发表时间:2011-12-23
- 期刊:
- 影响因子:4.8
- 作者:Ishihara, Takaya;Inoue, Jun;Inazawa, Johji
- 通讯作者:Inazawa, Johji
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{{ truncateString('IMOTO Issei', 18)}}的其他基金
Characterization of the esophageal carcinogenesis-promoting molecular switch existing inside the isoform of RNA-binding protein
RNA结合蛋白亚型内部存在的食管癌促进分子开关的表征
- 批准号:
16K15618 - 财政年份:2016
- 资助金额:
$ 2.5万 - 项目类别:
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Optimization of therapeutic strategy for esophageal squamous cell carcinoma based on modeling of intratumoral heterogeneity using omics data and genome editing
基于组学数据和基因组编辑的瘤内异质性建模优化食管鳞状细胞癌的治疗策略
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26293304 - 财政年份:2014
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$ 2.5万 - 项目类别:
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Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity
自发性低活动性动脉粥样硬化及心房血栓大鼠模型的分子遗传学分析
- 批准号:
25560368 - 财政年份:2013
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构建用于基因组分析的系统工具以确定导致大鼠各种疾病模型的基因
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24650238 - 财政年份:2012
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$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Construction of predictive algorithm for therapeutic effect and exploration of molecular targets in esophageal cancer by the next-generation integrated genome analysis
新一代整合基因组分析构建食管癌治疗效果预测算法及探索分子靶点
- 批准号:
23390325 - 财政年份:2011
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$ 2.5万 - 项目类别:
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Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction
通过基因组改变和癌基因成瘾的综合分析鉴定食管癌的靶基因
- 批准号:
20591564 - 财政年份:2008
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$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Exploration of diagnostic and therapeutic targets through array-based analyses for genomic and epigenomic alterations in esophageal squamous-cell carcinoma
通过基于芯片的食管鳞状细胞癌基因组和表观基因组改变分析探索诊断和治疗靶点
- 批准号:
18591457 - 财政年份:2006
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$ 2.5万 - 项目类别:
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Development and application of high-density genomic microarray system as a tool for human genome structural variation
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- 批准号:
17019014 - 财政年份:2005
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Identification of molecular target for diagnosis and therapy of esophageal squamous-cell carcinoma based on microarray technology.
基于微阵列技术识别食管鳞癌诊治分子靶点
- 批准号:
16591300 - 财政年份:2004
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$ 2.5万 - 项目类别:
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Molecular Mechanism of cIAP1 in Malignant Progression of Human Cancer
cIAP1在人类癌症恶性进展中的分子机制
- 批准号:
14570454 - 财政年份:2002
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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