Rapid screening of gene(s) related to the phenotype of model rats with high levels of voluntarily wheel running activity
Rapid screening of gene(s) related to the phenotype of model rats with high levels of voluntarily wheel running activity
批准号:
23650406
负责人:
IMOTO Issei
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 --
中文摘要
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英文摘要
In order to identify gene(s) and molecular pathway(s) possibly related to the phenotype of model rats with high levels of voluntarily wheel running activity(Spontaneously-Running-Tokushima-Shikoku, SPORTS) established from Wistar rats, we established a novel integrated screening system through combining exome sequencing using a next-generation sequencer, linkage analysis, and selection algorithm using genome and polymorphism databases. Through this study, we successfully established a novel screening system for rat genome analysis and identified a set of candidate genes related to the phenotype of SPORTS rats.
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徳島大学・大学院ヘルスバイオサイエンス研究部・人類遺伝学
德岛大学 健康生物科学研究生院 人类遗传学
DOI:
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影响因子:
--
作者:
[]
通讯作者:
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DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
メディカルサイエンス遺伝子検査学(IV染色体検査法-1染色体分染法-2染色法)
医学基因检测(IV染色体检测法-1染色体分割法-2染色法)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Uesugi A, et al, 井本逸勢]
通讯作者:
井本逸勢
DOI:
10.1158/0008-5472.can-11-0364
发表时间:
2011-10-15
期刊:
CANCER RESEARCH
影响因子:
11.2
作者:
[Tsuruta, Tomohiko, Kozaki, Ken-ichi, Inazawa, Johji]
通讯作者:
Inazawa, Johji
DOI:
10.1074/jbc.m111.251694
发表时间:
2011-12-23
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Ishihara, Takaya, Inoue, Jun, Inazawa, Johji]
通讯作者:
Inazawa, Johji
共 6 条
Characterization of the esophageal carcinogenesis-promoting molecular switch existing inside the isoform of RNA-binding protein
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批准号:16K15618
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.16万
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财政年份:2016
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负责人:IMOTO Issei
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依托单位:
Optimization of therapeutic strategy for esophageal squamous cell carcinoma based on modeling of intratumoral heterogeneity using omics data and genome editing
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批准号:26293304
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.23万
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财政年份:2014
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Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity
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批准号:25560368
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2013
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Construction of systematic tools forgenome analysesto determinegenes responsible for various disease model in rats
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批准号:24650238
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:IMOTO Issei
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依托单位:
Construction of predictive algorithm for therapeutic effect and exploration of molecular targets in esophageal cancer by the next-generation integrated genome analysis
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批准号:23390325
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2011
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依托单位:
Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction
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批准号:20591564
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2008
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依托单位:
Exploration of diagnostic and therapeutic targets through array-based analyses for genomic and epigenomic alterations in esophageal squamous-cell carcinoma
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批准号:18591457
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:IMOTO Issei
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依托单位:
Development and application of high-density genomic microarray system as a tool for human genome structural variation
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批准号:17019014
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$40.77万
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财政年份:2005
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负责人:IMOTO Issei
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依托单位:
Identification of molecular target for diagnosis and therapy of esophageal squamous-cell carcinoma based on microarray technology.
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批准号:16591300
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
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负责人:IMOTO Issei
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依托单位:
Molecular Mechanism of cIAP1 in Malignant Progression of Human Cancer
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批准号:14570454
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:IMOTO Issei
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依托单位:
海外基金