权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Thermoregulatory Mechanisms - from Cellular Process to Organism Response -

体温调节机制 - 从细胞过程到生物体反应 -

基本信息

批准号：
63304033
负责人：
NAGASAKA Tetsuo
金额：
$ 9.92万
依托单位：
Kanazawa University (1989-1990)Osaka University (1988)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

The followings have been clarified by this three-year co-operative research.(1) Thermoreceptive mechanisms within the hypothalamus using an isolated tissue.Modullary neurons receive cold information and control shivering. Control of higher brain activity by thermosensitive neurons in the hypothalamus.(2) Importance of the OVLT to induce fever by endogenous pyrogens. Acute phase response is controlled by thermoregulatory neurons in the hypothalamus.(3) Unilateral control of thermal saliva secretion by the hypothalamus. No unilateral control of thermal saliva secretion by skin warming. Tympanic temperature rises before thermal sweating by emotional stress. Sweat expulsion would be an indicator of central sweating activity. Unilateral suppression of sweating and fall of tympanic temperature after stellate ganglion blockade.(4) Selective brain cooling is evident in humans during hyperthermia. Importance of inward flowing of venous blood from the head and face skin to the intracranium.(5) Cross acclimation between cold and non-thermal stress. Importance of BAT for the cross acclimation. Negative feed back mechanisms from the central circulatory system to skin blood flow. Exercise at high temperatures suppress metabolism. pH and K-ion concentration change in blood after hypo- and hyperthermia.(6) Heat shock protein and species difference. Temperature dependency of NK-cells.Close relation of immune responses to temperature regulation.

这项为期三年的合作研究阐明了以下几点：(1)利用分离的组织研究下丘脑的感热机制。延髓神经元接收冷信息并控制颤抖。下丘脑的温度敏感神经元控制较高的脑活动。(2)OVLT在内源性热原诱导发热中的重要性。急性时相反应由下丘脑的体温调节神经元控制。(3)下丘脑对热唾液分泌的单侧控制。不能单方面通过皮肤变暖来控制热唾液的分泌。由于情绪紧张，鼓室温度在热出汗之前升高。排汗将是中枢出汗活动的一个指标。星状神经节阻断后单侧抑制出汗和鼓室温度下降。(4)高温时选择性脑降温作用明显。静脉血液从头面部皮肤向内流入脑内的重要性。(5)冷应激与非热应激的交叉适应。蝙蝠对交叉驯化的重要性。中央循环系统对皮肤血流的负反馈机制。高温运动会抑制新陈代谢。低温和高温后血液中pH和K-离子浓度的变化。(6)热休克蛋白和物种差异。自然杀伤细胞的温度依赖性。免疫反应与温度调节密切相关。