Mechanisms for Cooling the Brain Selectively and Hemodynamics of Emissary Venins

选择性冷却大脑的机制和使静脉的血流动力学

• 批准号: 06404018
• 负责人: NAGASAKA Tetsuo
• 金额: $ 16.58万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06404018/
• 关键词: Hyperthermia; Selective Brain Cooling; Emissary Venous Flow; Posture; Intrathoraci Pressure; Ventilatory Volume; 体温調節; 脳冷却機構

The purpose of this study was to investigate how the efficiency of selective brain cooling mechanisms in humans are influenced by the change in emissary venous flow due to the change in posture, intrathoracic pressure and ventilation. 1. Compared with in supine body position, emissary flow was higher and tympanic temperature became lower in upright position. With 6ﾟ-head down position, the changes were in opposite directions. 2. While occuluding the angular vein of one side and the facial vein at the alinasal level of another side, there occurred a disrepancy of tympanic temperatures in both sides, higher in the side where the angular vein was occluded. 3. In a negative breathing through a respirator with an inspiratory resistance or through a tank whose pressure was maintained negative, emissary flows increased and tympanic temperature became lower compared with the controls. 4. With hyperventilation, tympanic temperature became lower. The was observed when CO_2-added air was inspired, but the effect was not consistent in this case. 5. When the subject breathed through a nostril of one side, that of the other side was kept obstructed, the ipsilateral tympanic temperature became slightly lower. All these results suggest that enhancement of emissary venous flow was necessary important to increase efficiency of selective brain cooling in humans during hyperthermia.

本研究的目的是调查人类选择性脑冷却机制的效率是如何受到由于姿势、胸内压和通气变化引起的导静脉流量变化的影响。1.与仰卧位相比，直立位时导血流量增加，鼓膜温度降低。6 °头低位时，变化方向相反。2.阻断一侧的角静脉和另一侧的鼻翼面静脉时，两侧的鼓膜温度均不同程度地升高，其中阻断角静脉一侧的鼓膜温度较高。3.在通过具有吸气阻力的呼吸器或通过压力保持为负的罐的负呼吸中，与对照组相比，导流量增加，鼓膜温度降低。4.随着换气过度，鼓膜温度降低。当吸入含CO_2的空气时，观察到了这种效应，但这种效应并不一致。5.当受试者通过一侧鼓膜呼吸，另一侧鼓膜保持阻塞时，同侧鼓膜温度略有降低。所有这些结果都表明，在高温期间，加强导静脉流量对于提高人类选择性脑冷却的效率是必要的。

项目成果

平下政美: "運動時選択的脳冷却機構と個人差" 体力科学. 43. 136-137 (1994)

平下正美：“运动时的选择性大脑冷却机制和个体差异”《体质科学》43. 136-137 (1994)。

田辺 実: "化粧が高温環境下の発汗反応及び選択的脳冷却機構に及ぼす影響" コスメトロジー研究報告. 4. 122-129 (1996)

Minoru Tanabe：“高温环境下化妆对出汗反应和选择性大脑冷却机制的影响”美容研究报告4. 122-129 (1996)。

Nagasaka T: "Influence of changing intrathoracic pressure on emissary venous flow and selective brain cooling in hyperthermic conditions" Proc 14th ICB,1996.Ljubljana,Slovenis. (印刷中). (1997)

Nagasaka T：“高温条件下胸腔内压力变化对传导静脉血流和选择性脑冷却的影响”，Proc 14th ICB，1996 年，斯洛文尼亚卢布尔雅那（1997 年出版）。

秦 祐子: "重症熱傷患者の運動負荷にともなう発汗・体温調節." 理学療法学. 22(2). 57-62 (1995)

Yuko Hata：“与严重烧伤患者的运动负荷相关的排汗和体温调节。”22(2) (1995)。

Nagasaka T: "Selective barain cooling in hyperthermia:The mechanisms and medical implications." Medical Hypotheses. 50巻(January issue). (1998)

Nagasaka T：“高热中的选择性脑部冷却：机制和医学假设”，第 50 卷（1998 年）。