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Low protein diet, a factor deteriorating toxicities of chemicals

低蛋白饮食是加剧化学物质毒性的一个因素

基本信息

批准号：
02454204
负责人：
NOMIYAMA Kazuo
金额：
$ 3.9万
依托单位：
Jichi Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454204/
关键词：
low-protein diet benzene trichloroethylene cadmium lead mercury intensified toxicity hematopoiesis 感受性毒性増悪腎毒性

项目摘要

1)Intensified benzene toxicity by low-protein diet : Slight decrease in food protein aggravated benzene-induced leucopenia in rats, and significant decrease in food protein deteriorated benzene-induced health effects prominently.2)Intensified trichloroethylene toxicity by low-protein diet : Slight decrease in food protein worsened trichloroethylene-induced renal dysfunction in rats, and the decrease in food protein by half exacerbated tiicWoroethylene-induced hematopoietic effects as well.3)Intensified in vitro effects of benzene and trichloroethylene on hematopoiesis by low-protein diet : Hematopoiesis of rats fed low-protein diet were seriously depressed either by benzene or trichloroethylene metabolite in vitro compared with that of rats fed normal diet.4)Intensified cadmium toxicity by low-protein diet : Slight decrease in food protein worsened cadmium-induced renal dysfunction in rats, and significant decrease in food protein intensified cadmium-induced hepatic dysfunction.5)Intensified lead toxicity by low-protein diet : The lower the food protein level in rabbits was, the more aggravated lead-induced toxicity in body weight loss, lipid and hemoglobin metabolism abnormalities. Critical protein level to deteriorating cadmium toxicity could not be estimated, however.6)Intensified mercury toxicity by low-protein diet : The lower the food protein level in rabbits was, the more worsened mercury-induced renal dysfunction and lipid metabolism abnormality were. Critical protein level to deteriorating cadmium toxicity could not be estimated.

1)低蛋白饮食强化苯毒性：食物蛋白质的轻微减少加重苯引起的大鼠白细胞减少，食物蛋白质的显著减少加重苯引起的健康效应。2）低蛋白饮食强化三氯乙烯毒性：食物蛋白质的轻微减少会加重三氯乙烯诱导的大鼠肾功能障碍，食物蛋白质减半也加剧了苯和三氯乙烯诱导的造血作用。3）低蛋白饮食增强了苯和三氯乙烯对造血的体外作用：低蛋白饮食大鼠的造血功能在体外被苯或三氯乙烯代谢产物严重抑制。4）低蛋白饮食对镉毒性的强化作用：食物蛋白质的轻微减少会加重镉诱导的大鼠肾功能障碍，食物蛋白质的显著减少加剧了镉诱导的肝功能障碍。5）低蛋白饮食加剧了铅毒性：饲料蛋白质水平越低，铅对家兔的体重下降、血脂和血红蛋白代谢异常的毒性越加重。6）低蛋白饮食对汞毒性的强化作用：食物蛋白水平越低，汞致肾功能损害和脂代谢异常越严重。镉毒性恶化的临界蛋白质水平无法估计。