Low protein diet, a factor deteriorating toxicities of chemicals

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1)Intensified benzene toxicity by low-protein diet : Slight decrease in food protein aggravated benzene-induced leucopenia in rats, and significant decrease in food protein deteriorated benzene-induced health effects prominently.2)Intensified trichloroethylene toxicity by low-protein diet : Slight decrease in food protein worsened trichloroethylene-induced renal dysfunction in rats, and the decrease in food protein by half exacerbated tiicWoroethylene-induced hematopoietic effects as well.3)Intensified in vitro effects of benzene and trichloroethylene on hematopoiesis by low-protein diet : Hematopoiesis of rats fed low-protein diet were seriously depressed either by benzene or trichloroethylene metabolite in vitro compared with that of rats fed normal diet.4)Intensified cadmium toxicity by low-protein diet : Slight decrease in food protein worsened cadmium-induced renal dysfunction in rats, and significant decrease in food protein intensified cadmium-induced hepatic dysfunction.5)Intensified lead toxicity by low-protein diet : The lower the food protein level in rabbits was, the more aggravated lead-induced toxicity in body weight loss, lipid and hemoglobin metabolism abnormalities. Critical protein level to deteriorating cadmium toxicity could not be estimated, however.6)Intensified mercury toxicity by low-protein diet : The lower the food protein level in rabbits was, the more worsened mercury-induced renal dysfunction and lipid metabolism abnormality were. Critical protein level to deteriorating cadmium toxicity could not be estimated.