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Blood pressure elevation by heavy metals, its mechanism and prevention

重金属引起的血压升高、机制及预防

基本信息

批准号：
05454232
负责人：
NOMIYAMA Kazuo
金额：
$ 4.22万
依托单位：
Jichi Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454232/
关键词：
Cadmium Lead Mercury Blood Pressure Hypertensive heredity SHR rat remnant like lipoprotein atherosclerosis プラバスタチン動脈硬化

项目摘要

1) Both normotensive and spontaneously hypertensive (SHR) rats were given 15 g/day pelleted food containing CdCl_2 at a dose level of 0,3,30 or 300 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to 3 ppm Cd, but was depressed in SHR rats exposed to 300 ppm Cd. This might suggest that systolic blood pressure is accelerated by Cd at a lower dose level only in subjects with hypertensive heredity. Depression in systolic blood pressure may be a sign of Cd toxicity.2) Both normotensive and spontaneously hypertensive rats were given 15 g/day pelleted food containing PbCl_2 at a dose level of 0,3,30 or 300 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to 3 ppm Pb. This might suggest that systolic blood pressure is accelerated by Pb at a lower dose level only in subjects with hypertensive heredity. Supplemental studies suggested that age-related elevation in systolic blood pressure was accelerated more markedly by Pb at lower dose levels (0.3 and 1 ppm), and that blood pressure elevation may be accelerated by atherosclerosis through abnormal cholesterol metabolism.3) Both normotensive and spontaneously hypertensive rats were given 15 g/day pelleted food containing HgCl_2 at a dose level of 0,1,3 10 or 30 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to all levels of Hg. Biochemical data suggested that age-related elevation in systolic blood pressure may be accelerated by atherosclerosis through abnormal cholesterol metabolism induce by Hg.

1)正常血压大鼠和自发性高血压(SHR)大鼠按0、3、30和300ppm的剂量分别给予15g/d的含氯化镉颗粒食物。只有暴露于3ppm镉的自发性高血压大鼠的年龄相关性收缩压升高加速，而暴露于300ppm镉的自发性高血压大鼠的年龄相关性收缩压升高则受到抑制。这可能表明，只有在有高血压遗传的受试者中，较低剂量的镉才会加速收缩压。2)正常血压大鼠和自发性高血压大鼠均给予含PbCl2的颗粒状食物15g/d，剂量分别为0、3、30和300ppm。只有SHR大鼠暴露于3ppm铅时，与年龄相关的收缩压升高才会加速。这可能表明，只有在有高血压遗传的受试者中，较低剂量水平的铅才会加速收缩压。补充研究表明，在较低剂量水平(0.3和1ppm)，铅可更明显地加速与年龄相关的收缩压升高，动脉粥样硬化可能通过胆固醇代谢异常而加速血压升高。3)正常血压和自发性高血压大鼠均每天摄入15g/d含HgCl2的颗粒状食物，剂量分别为0、1、3、10或30 ppm。只有在暴露于所有水平汞的SHR大鼠中，与年龄相关的收缩压升高才会加速。生化数据表明，动脉粥样硬化可能通过汞诱导的胆固醇代谢异常加速了年龄相关性收缩压的升高。