Blood pressure elevation by heavy metals, its mechanism and prevention

点击翻译按钮获取中文摘要

1) Both normotensive and spontaneously hypertensive (SHR) rats were given 15 g/day pelleted food containing CdCl_2 at a dose level of 0,3,30 or 300 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to 3 ppm Cd, but was depressed in SHR rats exposed to 300 ppm Cd. This might suggest that systolic blood pressure is accelerated by Cd at a lower dose level only in subjects with hypertensive heredity. Depression in systolic blood pressure may be a sign of Cd toxicity.2) Both normotensive and spontaneously hypertensive rats were given 15 g/day pelleted food containing PbCl_2 at a dose level of 0,3,30 or 300 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to 3 ppm Pb. This might suggest that systolic blood pressure is accelerated by Pb at a lower dose level only in subjects with hypertensive heredity. Supplemental studies suggested that age-related elevation in systolic blood pressure was accelerated more markedly by Pb at lower dose levels (0.3 and 1 ppm), and that blood pressure elevation may be accelerated by atherosclerosis through abnormal cholesterol metabolism.3) Both normotensive and spontaneously hypertensive rats were given 15 g/day pelleted food containing HgCl_2 at a dose level of 0,1,3 10 or 30 ppm. Age-related elevation in systolic blood pressure was accelerated only in SHR rats exposed to all levels of Hg. Biochemical data suggested that age-related elevation in systolic blood pressure may be accelerated by atherosclerosis through abnormal cholesterol metabolism induce by Hg.