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Photodynamic Therapy with Focused Solar Ray

聚焦太阳光光动力疗法

基本信息

批准号：
02454297
负责人：
CHINZEI Tsuneo
金额：
$ 4.42万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454297/
关键词：
Photodynamic Therapy Solar Light Cancer Therapy Hematoporphyrin

项目摘要

Photodynamic therapy(PDT)of cancer with laser and photoreactive dye is very effective because of its high selectivity on damaging cancer tissue. Light source for PDT is not necessary to be laser. Light source with any wave length, which can excite photoreactive dye, will do. Solar light is one of such light source. In this study, we developed equipment which focused solar light to introduce solar ray to patients. With this equipment, westudied on PDT with solar ray.Solar light, filtered with infrared filter, was reflected with main miffor of 180 mm diameter and was focused to 18 mm spot. On this stage, maximum power of 2.3W, mean power of I. IW was gained. On next stage, it collimated to 0.9 mm diameter optical fiber. Mean light power on output side of optical fiber was 0.26W. This equipment traced sun and maintained its output light power for 5 hours.Focused solar ray was irradiated to cancer tissue on rat and effect of irradiation was studied pathohistologically. As PDTgroup, 4 mg/kg hematoporphyrin -(HPD)was administrated in abdominal cavity on 24 hours before irradiation. As control group, no HPD was administrated before irradiation. The irradiation was performed to subcutaneous cancer through skin for 30 minutes. Immediate change was not found on both group after irradiation.Cancer reduction was found at 24 hours after irradiation on PDT group. After 1 week, cancer tissue was reduced by half. Histrogially, necrosis of cancer cell and infiltration of white blood cell were observed.Usually, dye lasers have been used as PDT light source. The excitive wave length of HPD spread through visible light. In this basic study, solar light which covers this excitation range, causes effective PDT on cancer therapy.

利用激光和光敏染料的光动力学疗法（PDT）对肿瘤组织的损伤具有高度的选择性，是一种非常有效的治疗方法。PDT的光源不一定是激光。任何波长的光源，只要能激发光敏染料，都可以。太阳光就是这样的光源之一。在这项研究中，我们开发了一种设备，可以聚焦太阳光，将太阳光线引入患者体内。利用该装置进行了太阳光PDT的研究，太阳光经红外滤光片滤光后，由直径为180 mm的主反射镜反射，聚焦成18 mm的光斑。在该平台上，最大功率为2.3W，平均功率为I. IW已经获得。在下一阶段，它准直到0.9 mm直径的光纤。光纤输出端的平均光功率为0.26W。该装置跟踪太阳并保持输出光功率5 h，用聚焦太阳射线照射大鼠癌组织，观察照射后的病理组织学变化。PDT组于照射前24 h腹腔注射血卟啉（HPD）4 mg/kg。对照组在照射前不给予HPD。通过皮肤对皮下癌进行照射30分钟。两组照射后即刻未见明显变化，PDT组照射后24小时即见肿瘤缩小。1周后，癌组织减少一半。组织学上可见癌细胞坏死和白色血细胞浸润。HPD的激发波长在可见光范围内扩展。在这项基础研究中，覆盖该激发范围的太阳光在癌症治疗中引起有效的PDT。