TOXICITY OF BUPIVACAINE, WITH REFERENCE TO ITS METABOLITES

布比卡因的毒性及其代谢物

• 批准号: 02454361
• 负责人: ASADA Akira
• 金额: $ 0.96万
• 依托单位: OSAKA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454361/
• 关键词: INDOCYANINE GREEN; HEPATIC FAILURE; PHAMACOKINETICS; TWO COMPARTMENT MODEL; MOMENT ANALYSIS; ブピバカイン; 2.6ーピベコロキシリダイド; ラット; 2,6ーpipecoloxylidide(PPX); ラット肝ミクロゾ-ム

Pharmacokinetics of intravenously administered indocyanine green (ICG) was studied in 4 ICU patients with hepatic failure. Elevated serum bilirubin, anmonia was observed and their consciousness level was hepatic coma grade II-III.0.5 mg/kg ICG was intravenously administered and its serum concentration was measured by high performance liquid chromatography. Decreased clearance and elevated distribution half life, elimination half life was observed with two compartment model. Prolonged mean residential time, increased volume of distribution, decreased clearance was observed by compartment analysis. Two compartment model was more suitable for the analysis of pharmacokinetics of ICG, volume of distribution was expanded more than the volume of plasmsa, suggesting that ICG was distributed to the extravascular space in these patients. From these results, liver should be considered as the central compart, not as the peripheral compartment in the pharmacokinetic model.

对4例重症监护病房（ICU）肝衰竭患者静脉注射吲哚菁绿色（ICG）的药代动力学进行了研究。观察到血清胆红素升高、贫血，意识水平为肝昏迷II ~ III级。静脉注射ICG 0.5 mg/kg，用高效液相色谱法测定其血清浓度。采用二室模型观察药物清除率降低，分布半衰期和消除半衰期延长。房室分析显示平均滞留时间延长，分布容积增加，清除率降低。二室模型更适合ICG的药代动力学分析，分布容积较血浆容积扩大，提示ICG在这些患者体内分布于血管外空间。根据这些结果，在药代动力学模型中，肝脏应被视为中央室，而不是外周室。

项目成果

山本 勲: "肝不全患者におけるインドシアニングリーン(ICG)の分布および排池半減期の著明の延長" Pharmacoanestheslology. 5. 50-51 (1992)

Isao Yamamoto：“肝衰竭患者中吲哚菁绿 (ICG) 的分布和消除半衰期显着延长”Pharmacoanestheslology 5. 50-51 (1992)。

Shin-ichi Nishi: "Usefulness of ICG kinetics using ICG clearance meter in ICU." ICU and CCU. 16-12. 1197-1203 (1992)

Shin-ichi Nishi：“在 ICU 中使用 ICG 清除计来了解 ICG 动力学的有用性。”

Isao Yamamoto: "The estimation of a fraction of portacaval shunt flow in man using moment analysis of ICG." Proceedings of the 13th Japanese Symposium on Biotransformation and Toxicity of Anesthetics. 13. 85-88 (1992)

Isao Yamamoto：“使用 ICG 矩分析估计人体门静脉分流的一部分。”

西 信一: "ICGクリアランスメーターを用いたICUでのICG薬物動態解析の有用性" ICUとCCU. 16. 1197-1203 (1992)

Shinichi Nishi：“使用 ICG 清除计进行 ICU 中 ICG 药代动力学分析的有用性”ICU 和 CCU。 16. 1197-1203 (1992)

西 信一: "血中薬物動態のモニタリング" 臨床モニター. 3. 249-256 (1992)

Shinichi Nishi：“血液药代动力学的监测”临床监测3. 249-256 (1992)。