BIOMECHANICAL SIMULATION MODELS OF MUCOUS MEMBRANE AND PERIODONTAL MEMBRANE BASED ON THEIR ANATOMICAL STRUCTURES

本文研究了口腔粘膜和牙周膜的力学特性，并结合其解剖结构建立了仿真模型，得到了以下结果：1。在粘膜上，我们制作了一个实验模型，由硅橡胶和石膏制成，并配备了微型压力传感器。测量了不同形状压头压入时的压力分布。此外，猪粘膜用于调查，其中表面变形测量的激光位移计。根据实验结果建立了计算机仿真模型，实现了压力向平头压头边缘的下降.在牙周膜上，建立了牙齿移动的数学模型。假设牙齿的载荷-位移关系，推导出牙周膜的局部压缩比，确定微循环条件，进而推导出骨吸收率。该模型能够区分过度正畸力引起的骨吸收和最佳正畸力引起的骨吸收.在适应性骨重建方面，建立了耦合机械刺激和化学介质的模拟模型。基于该模型进行了计算机仿真，实现了相对力矩的骨肥大和偏心压缩载荷的自适应重塑等过程.在体外培养系统上，建立了兔滑膜成纤维细胞的培养模型。利用胶原蛋白模拟体内环境，阐明了细胞在应力环境下伸长方向的改变，细胞沿拉伸方向沿着迁移和增殖等现象。

We study here the mechanical properties of mucous membrane and periodontal membrane and construct the simulation models with the knowledge of their anatomical structures, and obtained the following results:1. On the mucous membrane, we made a experimental model made of silicone elastomer and plaster, and equipped it by the miniature pressure sensors. The pressure distributions are measured in the cases of indentations by the indentors of various shapes. Furthermore, porcine mucous membranes are utilized for investigations in which surface deformations are measured by the laser displacement meter. The computer simulation model is constructed based on the experimental results, which enable us to realize the pressure decrease toward the edge of the flat indentors.2. On the periodontal membrane, the mathematical model for tooth movement is constructed. Assuming the load-displacement relation for a tooth, the local compression ratios of periodontal membrane are deduced and the micro circulation conditions are determined, then the bone resorption rates are deduced following the model. The model enable us to distinguish the undermining bone resorption by the excessive orthodontic force and the direct bone resorption by the optimal orthodontic force.3. On the adaptive bone remodeling, a simulation model is constructed which couples the mechanical stimuli and chemical mediators. The computer simulations are carried out based on the model, and such processes are realized as the bone hyperthrophy by the relatitive moment and the adaptive remodeling by the excentric compresive load.4. On the in vitro system, the cell culture model is established for the rabbit synovial fibroblasts. Collagen is utilized to simulate the in vivo environments, and such phenomana are clarified that the change of cell elongation direction in acordance to the stress environment, the migration and proliferation along the tensile direction.