Insolubilization and Adhesive Properties of Biomimetic Collagen asan Artificial Periodontal Membrane

仿生胶原人工牙周膜的不溶性和粘附性能

• 批准号: 03670912
• 负责人: OKAZAKI Masayuki
• 金额: $ 1.09万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670912/
• 关键词: Artificial Periodontal; Biomimetic; Collagen; Insolubilization; Bio-adhesion; UV照射; コラ-ゲン; 波形デ-タ処理システム; バイオミメティックス

Recently, our society is growing into and aged society. More people are losing their teeth and must use artificial prothetics such as dentures and artificial tooth roots. It is not easy to develop an excellent restorative material for periodontal membrane because the natural periodontal membrane contributes to connect tooth root and alveolar bone, and also acts as a xhock absorber for exterior force. The observation of the periodontal mebrane using scanning electron mictoscope clearly showed such complicate bio-adhesion. As the results of our investigation concerning the artificial periodontal membrane, insolubilixation of collagen and its adhesion to apatite-collagen composites were successfully achieved by UV-ray irradiation and plasma treatment. However, since adhesive strength and shape problem of artificial periodontal membrane-tooth root system have not been resolved. further investigations are in progress.

近年来，我们的社会正在步入老龄化社会.越来越多的人正在失去他们的牙齿，必须使用人工修复术，如假牙和人工牙根。天然的牙周膜不仅是连接牙根和牙槽骨的重要材料，而且还具有吸收外力的作用，因此要研制出性能优良的牙周膜修复材料并不容易。扫描电镜对牙周膜的观察清楚地显示了这种复杂的生物粘附。作为我们的调查结果，关于人工牙周膜，胶原蛋白的不溶性和其粘附磷灰石-胶原复合材料成功地实现了紫外线照射和等离子体处理。然而，由于人工牙周膜-牙根系统的粘接强度和形状问题一直没有得到解决。警方现正作进一步调查。

项目成果

岡崎 正之: "フッ素化アパタイトの結晶学的性質に及ぼすMg^<2+>,Fe^<2+>,CO_3^<2+>イオンの影響" 生体材料. 10. 247-255 (1992)

Masayuki Okazaki：“Mg^<2+>、Fe^<2+>、CO_3^<2+> 离子对氟化磷灰石晶体学性质的影响”生物材料。10. 247-255 (1992)

岡崎 正之,高橋 純造,木村 博: "不均質系Mg含有アパタイトの結晶学的性質" JJSMgR. 11. 59-69 (1992)

Masayuki Okazaki、Junzo Takahashi、Hiroshi Kimura：“异质含镁磷灰石的晶体学性质”JJSMgR 11. 59-69 (1992)。

岡崎 正之,高橋 純造,木村 博: "アパタイトの物理化学的性状におよぼすMg^<2+>,CO_3^<2ー>,F^-イオンの相互作用" マグネシウム. 10. 7-18 (1991)

Masayuki Okazaki、Junzo Takahashi、Hiroshi Kimura：“Mg^<2+>、CO_3^<2-> 和 F^- 离子对磷灰石物理化学性质的相互作用”镁。 10. 7-18 (1991)

M.Okazaki and H.Ohmae: "Insolubilized Properties of Collagen Membranes as an Artificial Periodontal Membrane and their Dynamic Estimation" Artificial Organ Today. (in press).

M.Okazaki 和 H.Ohmae：“作为人工牙周膜的胶原膜的不溶性特性及其动态估计”《今日人工器官》。

M.Okazaki: "Crystallographic Morphology of Heterogeneous Fluoridated Carbonate Apatites" J Dent Res. 72. 1285-1290 (1993)

M.Okazaki：“异质氟化碳酸盐磷灰石的晶体形态”J Dent Res。