Development of a centrifugal pump containing an artificial lung

开发含有人工肺的离心泵

• 批准号: 04454352
• 负责人: TAENAKA Yoshiyuki
• 金额: $ 3.71万
• 依托单位: National Cardiovascular Center Research Institute (1992, 1994)Osaka Prefectural Radiation Research Institute (1993)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454352/
• 关键词: artificial lung; blood pump; profound heart and lung failure; animal experiment; centrifugal pump; surface heparinization; metabolic function of the lung; antithrombogenicity; 心肺置換; プロスタグランディン; 経皮的心肺補助; 循環虚脱; 心肺蘇生; V-Aバイパス

The purpose of this study is to develop a centrifugal pump containing an artificial lung. Hollow fibers for the oxygenator was placed along inner surface of the outer wall of the blood casing of the centrifugal pump. in order to have a sufficient output performance a round-shaped partition with slits were applied between the impeller and the hollow fibers. The surface of the oxygenator was heparinized for good antithrombogenicity. The surface was evaluated in animal experiments as a veno-arterial bypass without systemic heparinization and the results proved acceptable antithrombogenicity. In vivo performances of an integarated artificial heart-and-lung device and methods of the management of recipients of such a device were also examined in chronic animal experiments with goats. The results suggested good in vivo properties of the system and necessity of further research to clarify the importance metabolic function of the lung.

本研究的目的是研制一种含人工肺的离心泵。用于氧合器的中空纤维沿着离心泵的血液壳体的外壁的内表面放置。为了具有足够的输出性能，在叶轮和中空纤维之间应用具有狭缝的圆形隔板。氧合器表面肝素化，具有良好的抗血栓性。该表面在动物实验中作为静脉-动脉旁路进行了评价，未进行全身肝素化，结果证明具有可接受的抗血栓性。还在山羊慢性动物实验中检查了一体化人工心肺装置的体内性能和这种装置的接受者的管理方法。结果表明，该系统具有良好的体内性能，需要进一步研究以阐明肺的重要代谢功能。

项目成果

赤城 治彦、高野 久輝、他: "人工肺を内蔵した遠心ポンプの開発" 膜型肺. 15. (1993)

Haruhiko Akagi、Hisaki Takano 等人：“内置人工肺的离心泵的开发”15。（1993 年）

高野久輝,赤城治彦: "膜型肺 ハードウエアの現況と展望" 膜型肺. 15. 44-48 (1993)

Hisaki Takano、Haruhiko Akagi：“膜肺硬件的现状和前景”膜肺。 15. 44-48 (1993)

赤城治彦,高野久輝,他: "緊急的心肺補助での使用を目的とした人工肺内蔵遠心ポンプの開発" 膜型肺. 15. 37-39 (1993)

Haruhiko Akagi、Hisaki Takano 等人：“用于紧急心肺支持的内置人工肺的离心泵的开发”Membrane Lung。

馬場雄造,赤城治彦,他: "長期使用を目的とした人工肺の開発" 膜型肺. 15. 98-102 (1993)

Yuzo Baba、Haruhiko Akagi 等人：“长期使用的人工肺的开发”Membrane Lung。15. 98-102 (1993)

高野 久輝、赤城 治彦: "模型人工肺ーハードウエアの現況と展望ー" 膜型肺. 15. (1993)

Hisaki Takano、Haruhiko Akagi：“模型人工肺 - 硬件的现状和前景”15。（1993）