Influences of Mid-to-Long Term Nonpulsatile Circulation on Function and Structure of the Living Body

中长期非搏动循环对生命体功能和结构的影响

• 批准号: 10470280
• 负责人: TAENAKA Yoshiyuki
• 金额: $ 4.1万
• 依托单位: National Cardiovascular Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470280/
• 关键词: nonpulsatile circulation; Aorta; Circulatory control; Circadian rhythm; Chronomedicine; Vascular tonus; Autonomic nerve; Peripheral vessels; 人工心臓; 生体適合化; 血液破壊; 流れの可視化; 数値解析法; 血栓形成; 解剖学的適合性; 電磁波; 人工循環; 無拍動流循環; 循環調節; 血管トーヌス; 血管収縮性; 末梢循環

Influences of mid-to-long term nonpulsatile circulation on function and structure of the living body were investigated especially in systemic circulation. Systemic vascular resistance was slightly decreased but other hemodynamics, peripheral organ, circulation, tissue metabolism and humoral circulatory control were not affected. Vascular tonus was maintained although constrictive function of the vascular system was reduced. Autonomic nervous sytem was also investigated. Circadian rhythm was well maintained except for rennin rhythm. Aortic wall thickness was reduced and atrophic changes of the wall smooth muscle cell was observed. Middle size arteries was not influence but peripheral vessels around the juxta-glommerular apparatus showed proliferation in the kidney.

研究了中、长期无搏动循环对机体功能和结构的影响，特别是体循环的影响。全身血管阻力略有下降，但其他血流动力学、外周器官、循环、组织代谢和体液循环控制不受影响。尽管血管系统的收缩功能降低，但血管紧张性得以维持。并对自主神经系统进行了研究。除凝乳酶节律外，昼夜节律维持良好。主动脉壁增厚，平滑肌细胞萎缩。肾内中等动脉无明显影响，但肾小球旁器周围血管增生。

项目成果

Nishimura T, Tatsumi E, Nishinaka T, Taenaka Y, Masuzawa T, Nakata M, Takano H.: "Diminished vasoconstrictive function caused by long-term nonpulsatile left heart bypass."Artificial Organs. 23 (8). 722-726 (1999)

Nishimura T、Tatsumi E、Nishinaka T、Taenaka Y、Masuzawa T、Nakata M、Takano H.：“长期非搏动性左心搭桥导致血管收缩功能减弱。”人工器官。

西村 隆: "定常流左バイパス時の脈圧の減少が大動脈壁の力学的特性に及ぼす影響に関する研究" 日本機械学会第76期全国大会講演論文集(II). 98(3). 269-270 (1998)

Takashi Nishimura：“稳定流量左旁路期间脉压降低对主动脉壁机械性能的影响研究”日本机械工程学会第76届全国会议论文集（II）98（3）。 269-270 (1998)

Nishinaka T, Koyanagi H, Tatsumi E, Taenaka Y, Takano H.: "Effect of prolonged nonpulsatile left heart bypass on vascular control status."J Artif Organs. 3. 34-38 (2000)

Nishinaka T、Koyanagi H、Tatsumi E、Taenaka Y、Takano H.：“长期非搏动性左心旁路对血管控制状态的影响。”J Artif Organs。

Nishimura T: "Diminished vasoconstrictive function caused by long-term nonpulsatile left heart bypass"Artificial Organs. 23(8). 722-726 (1999)

Nishimura T：“长期非搏动性左心搭桥导致血管收缩功能减弱”人工器官。

Nishinaka T: "Cardiac autonomic nervous function during long-term nonpulsatile left heart bypass"Artificial Organs. 23(6). 500-503 (1999)

Nishinaka T：“长期非搏动左心搭桥期间的心脏自主神经功能”人工器官。