Improvement of Biocompatibility of Mechanical Pump Systems for Artificial Hearts

人工心脏机械泵系统生物相容性的改善

• 批准号: 10357012
• 负责人: TAENAKA Yoshiyuki
• 金额: $ 16.83万
• 依托单位: National Cardiovascular Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10357012/
• 关键词: Artificial Heart; Heat; Hemolysis; Flow visualization; Computational fluid dynamics; Thrombus; Anatomical fitting; Electromagnetic wave; 無拍動流; 人工循環; 循環調節; サーカディアンリズム; 時間医学; 血管系トーヌス; 自律神経; 末梢血管; 生体適合化; 解剖学的適合性

Biocompatibility of mechanical blood pump systems was improved for artificial hearts aiming at a tether free and totally implantable system with a transcutaneous energy transmission system. Reduction of hemolysis was realized in a centrifugal blood pump system with flow visualization and computational fluid dynamic techniques. Antithrombogenicity was also improved from the standpoint of fluid dynamics and with the application of a new surface heparinization method. Anatomical fitting was improved by the investigation of three dimensional analyses of the human body with computational tomography. Influences of heat and electromagnetic wave were also studied and harmful influences were not observed in out artificial heart system.

人工心脏的机械血泵系统的生物相容性得到了改善，旨在实现具有经皮能量传输系统的无绳且完全植入的系统。通过流动可视化和计算流体动力学技术，在离心血泵系统中实现了溶血的减少。从流体动力学的角度来看，通过应用新的表面肝素化方法，抗血栓形成性也得到了改善。通过利用计算机断层扫描对人体进行三维分析研究，改进了解剖学拟合。还研究了热和电磁波的影响，在我们的人工心脏系统中没有观察到有害影响。

项目成果

Tsukamoto Y: "Computational flud dynamics analysis of a centrifugal blood pump with washout holes."Artificial Organs. 24(8). 648-652 (2000)

Tsukamoto Y：“带有冲洗孔的离心血泵的计算流体动力学分析。”人工器官。

Wakisaka Y, Taenaka Y, Chikanari K, Okuzono Y, Nishimura T, Endo S, Nakatani T, Takano H: "Intrathoracic and intraabdominal wall implantation of a centrifugal blood pump for circulatory assist."Artificial Organs. 22 (6). 493-497 (1998)

Wakisaka Y、Taenaka Y、Chikanari K、Okuzono Y、Nishimura T、Endo S、Nakatani T、Takano H：“胸腔内和腹腔内壁植入离心血泵以辅助循环。”人工器官。

Tsukamoto Y, Ito K, Sawairi T, Konishi Y, Yamane T, Nishida M, Masuzawa T, Tsukiya T, Endo S, Taenaka Y.: "Computational fluid dynamics analysis of a centrifugal blood pump with washout holes."Artif Organs. 24 (8). 648-652 (2000)

Tsukamoto Y、Ito K、Sawairi T、Konishi Y、Yamane T、Nishida M、Masuzawa T、Tsukiya T、Endo S、Taenaka Y.：“带冲洗孔的离心血泵的计算流体动力学分析。”Artif Organs。

Tatsumi E: "Current status of development and in ivo evaluation of the National cardiovaecular Center electrohydraulic total artificial heart system."J Artif Organs. 3. 62-69 (2000)

Tatsumi E：“国家心血管中心电液全人工心脏系统的开发现状和体内评估。”J Artif Organs。

Tatsumi E, Taenaka Y, Uesho K, Homma A, Nishinaka T, Kakuta Y, Tsukiya T, Takano H, Masuzawa T, Nakamura M, Koshiji K, Fukui Y, Tsukahara K, Tsuchimoto K, Wakui H: "Current status of development and in vivo evaluation of the National Cardiovascular Center

Tatsumi E、Taenaka Y、Uesho K、Homma A、Nishinaka T、Kakuta Y、Tsukiya T、Takano H、Masuzawa T、Nakamura M、Koshiji K、Fukui Y、Tsukahara K、Tschimoto K、Wakui H：“开发现状