Miniaturization and Performance Enhancement of the Magnetically Levitated Centrifugal Pump as an Implantable Ventricular Assist Device

作为植入式心室辅助装置的磁悬浮离心泵的小型化和性能增强

基本信息

批准号：
15390425
负责人：
TAENAKA Yoshiyuki
金额：
$ 8.83万
依托单位：
Research Institute of National Cardiovascular Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The purpose of the present study is enhancement of the performances and the biocompatibility of the centrifugal pump with magnetically levitated impeller as a left ventricular assist device, with the final goal of development of an implantable ventricular assist system.The primary results obtained through this study are as follows;1. Miniaturization and Stability Enhancement of the Levitation Controlling CircuitThe electronic circuits which control both radial levitation and rotation of the rotor (impeller) were designed to be implemented in the compact centrifugal pump. Numerical Simulations were carried out to obtain the optimized values of the inner/outer diameters of the stator, and the number of turns. The test rig pump was designed based on the analyses results, and the sufficient hydrodynamic performances were realized as a left ventricular assist device.2. The zero-power control method was employed and implemented into the present levitation system. The zero-power system sets t … More he control target onto the position where the radial fluid forces are minimized, and consequently save the electric power required to the levitation system. We built the numerical modeling of the electromagnetic components and then obtained the optimized thickness of the permanent magnets, diameter of the stator, and the number of turns of electric coils. Finally the diameter of the stator was set to 55 mm and we have succeeded in reducing the total electric power to 11 watts.3. The smallest clearance of the blood passage was 0.5 mm at the gap between the stator and the rotor. The hemolysis tesing was carried out to confirm the mechanical damage exerted to the red blood cells are within tolerable range toward clinical application. The results showed that the mechanical blood damage caused by the pump are compatible to that by the commercially available pump (Medtronic BP-80) at the flow rate of 5.0 L/min against the pressure head of 100 mmHg.4. The method of estimating the flow rate of the pump are also investigated. As the result of the zero-power control, the impeller positions shift to the balanced position on each flow condition. We have found the displacement of the impeller from the geometrical center are proportional to the flow rate. This basic founding can be developed into the flow rate measurement system which does not require any flow meter in the system. Less

本研究的目的是增强性能和带有磁性叶轮作为左心室辅助装置的离心泵的性能和生物相容性，并最终的目标是开发可植入的心室辅助系统。通过本研究获得的主要结果如下：1。控制电路的悬浮电路的微型化和稳定性增强了控制转子的径向悬浮和旋转（叶轮）的电子电路，以在紧凑的离心泵中实现。进行数值模拟以获得定子内部/外径的优化值，并获得转弯数。根据分析结果设计了测试钻机泵，并实现了足够的流体动力性能为左心室辅助装置。2。进行了零功率控制方法并将其实施到当前的悬浮系统中。零功率系统设置了t…更多地将目标控制到最小化径向流体力的位置，从而节省了悬浮系统所需的电力。我们构建了电子组件的数值建模，然后获得了永久磁体的优化厚度，定子的直径和电线的转弯数。最后，定子的直径设置为55毫米，我们成功地将总电力降低到11瓦3。在定子和转子之间的间隙处，血液通道的最小清除率为0.5毫米。进行溶血效果以确认对红细胞施加的机械损伤在临床应用方面可容忍的范围内。结果表明，泵造成的机械血液损伤与5.0 L/min的流速为100 mmHg.4的流速为5.0 l/min。还投资了估计泵流量的方法。作为零功率控制的结果，叶轮位置转移到每个流条件上的平衡位置。我们发现，叶轮从几何中心的位移与流速成正比。这个基本的基础可以发展到流速测量系统中，该系统不需要系统中的任何流量计。较少的