A study on pathophysiology of circulatory dysfunction in immature fetuses by extrauterine fetal incubation

宫外孵化未成熟胎儿循环功能障碍的病理生理学研究

• 批准号: 05454344
• 负责人: OKAI Takashi
• 金额: $ 3.9万
• 依托单位: UNIVERSITY OF TOKYO
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454344/
• 关键词: artificial placenta; fetus; cerebral blood flow; colored microsphere; oxygen consumption; ECMO; ECMO; 胎児循環; 胎動抑制; 異常胎仔

1. The condition of isolated goat fetuses with umibilical arteriovenous extracorporeal membrane oxygenation was investigated. (1) Umbilical arteriovenous extracorporeal membrane oxygenation enabled isolated goat fetuses to survive for three weeks. (2) It was confirmed that fetal circulation was maintained with the patent ductus arteriosus during the extrauterine incubation period. (3) The fetuses maintained stable circlatory and respiratory paramaters after the postoperative period. (4) Oxygen consumption in the incubated fetuses was almost the same as the level in the intrauterine fetuses.2. Effects of repeated umbilical cord occlusion on brain circulation in fetal goats were investigated by colored microsphere technique. (1) The blood flow to the cerebral cortex, white matter, cerebellum and medulla increased by 200-300% respectively during umbilical cord occlusion. (2) The regional blood flow in the brain increased further after the release of cord occlusion. However, it tended to decrease with the repetition of cord occlusion.

1。研究了孤立的山羊胎儿的状况，并研究了体外膜外膜氧合。 （1）体外膜氧合的脐动静脉内氧合使孤立的山羊胎儿生存了三个星期。 （2）可以证实，在外部孵育期间，胎儿循环与动脉导管保持了胎儿循环。 （3）术后胎儿在术后保持稳定的循环和呼吸道参数。 （4）孵育胎儿中的氧气消耗几乎与宫内胎儿的水平相同2。通过有色微球技术研究了反复的脐带阻塞对胎儿山羊脑循环的影响。 （1）在脐带阻塞期间，血液流向大脑皮层，白质，小脑和延髓的血液分别增加了200-300％。 （2）释放脐带闭塞后，大脑中的区域血流进一步增加。但是，它往往会随着绳索闭塞的重复而减少。

项目成果

N.Unnc,T.okai,et al.: "Development of an Artificial Placenta:Endocrine Responses of Goat Fetuses during Long-Term Extrauterine Incutation with Umbilical Arteriovenous Extracorporeal Membrane Oxygenation" Endocrine Journal. 41(Suppl). S69-S76 (1994)

N.Unnc、T.okai 等人：“人工胎盘的发育：采用脐动静脉体外膜氧合长期宫外切割过程中山羊胎儿的内分泌反应”内分泌杂志。

Unno N, Kuwabara Y, Okai T, et al: "Development of an artificial placenta : Endocrine responses of goat fetuses furing long-term extrauterine incubation with umbilical arteriovenons sxtracorpored membrane Oxygenatis" Eudocrine Journal. 41. S69-S76 (1994)

Unno N、Kuwabara Y、Okai T 等人：“人工胎盘的发育：长期宫外孵化与脐动脉体外膜氧合的山羊胎儿的内分泌反应”Eucocrine Journal。

海野信也、岡井崇、他: "臍帯動静脈A・V ECMOによるヤギ未熟胎仔の長期間子宮外保育法-胎動抑制法の検討" 人工臓器. 22. 876-879 (1993)

Shinya Unno、Takashi Okai 等人：“使用脐带动静脉 A/V ECMO 进行早产山羊胎儿的长期宫外孵化 - 胎动抑制方法的研究”《人工器官》22. 876-879 (1993)。

Nobuya Unno, Yoshinori Kuwabara, Takashi Okai, Hirotoshi Nakayama, Akihiko Kikuchi, Yumiko Narumiya, Shiro Kozuma, Yuji Taketani, Masanori Tamura: "Development of an artificail Placenta : Survival of isolated goat fetuses for three weeks with unbilical A-

Nobuya Unno、Yoshinori Kuwabara、Takashi Okai、Hirotoshi Nakayama、Akihiko Kikuchi、Yumiko Narumiya、Shiro Kozuma、Yuji Taketani、Masanori Tamura：“人工胎盘的开发：离体山羊胎儿在脐带 A 中存活三周

N.Unno,T.Okai et al: "Development of an Arrificial:Endocrine Response" Endocrine Journal. 41. 69-76 (1995)

N.Unno、T.Okai 等人：“内分泌反应的发展”内分泌杂志。