A basic study of application of high-intensity focused ultrasound for fetal therapy

高强度聚焦超声在胎儿治疗中应用的基础研究

基本信息

  • 批准号:
    18200035
  • 负责人:
  • 金额:
    $ 23.21万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 财政年份:
    2006
  • 资助国家:
    日本
  • 起止时间:
    2006 至 2008
  • 项目状态:
    已结题

项目摘要

本研究は強出力集束超音波(HIFU)を用いて血流依存性疾患(胎児腫瘍など)、胎児閉塞性尿路障害、胎児腔水症、双胎間輸血症候群に対する胎児治療に向けた基礎実験を行うことで臨床応用が可能かどうかを知ることを目的に行われた。実験結果から胎児胎内の血流遮断が可能なこと、血流遮断により腫瘍の増殖抑制ができることを確認した。また胎児膀胱皮膚瘻の作製、胎盤表面血管の閉塞が可能なことも確認された。以上よりHIFUの低侵襲胎児治療への臨床応用の可能性が示された。
In this study, cluster ultrasound (HIFU) was used to detect fetal blood flow-dependent disorders (fetal blood flow-dependent disorders), fetal obstructive urinary tract disorders, fetal cavity water, and interfetal septicemia syndrome. The purpose of this study was to evaluate the efficacy of cluster ultrasound in the diagnosis and treatment of fetal diseases. The results showed that the blood flow occlusion in the fetus may be abnormal, and the blood flow occlusion may not result in colonization inhibition. The bladder skin of the fetus is not covered, and the blood vessels on the surface of the fetus are blocked. The above "HIFU" low-invasion fetal treatment, "bed" and "possibility" are used to show the possibility.

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Basic study of high-intensity focused ultrasound for fetal therapy
高强度聚焦超声胎儿治疗的基础研究
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    長崎幸夫;吉田吉行;大石基;斯波真理子;Kiyotake Ichizuka
  • 通讯作者:
    Kiyotake Ichizuka
The study of reducing effect of tumor by ablation of the tumor-feeding artery using HIFU sonication : Potential for the therapy of uterine fibroid
使用 HIFU 超声消融肿瘤供血动脉来减少肿瘤效果的研究:治疗子宫肌瘤的潜力
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Teramura;Y.;Kaneda;Y.;and Iwata;H.;Kiyotake Ichizuka
  • 通讯作者:
    Kiyotake Ichizuka
Application of high-intensity focused ultrasound for fetal vascular occlusion : Potential for treatment of fetal diseases related to abnormal blood flow supply.
高强度聚焦超声在胎儿血管闭塞中的应用:治疗与血流供应异常相关的胎儿疾病的潜力。
Application of high-intensity focused ultrasound for fetal therapy-experimental study using animal model for obstructive uropathy-
高强度聚焦超声在胎儿治疗中的应用-梗阻性尿路病动物模型实验研究-
  • DOI:
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    0
  • 作者:
    K. Yamamoto;and J. Ando;Nishimura T. et. al.;Kiyotake Ichizuka
  • 通讯作者:
    Kiyotake Ichizuka
Sequential changes in rat femoral artery blood flow and tissue degeneration after exposure to high-intensity focused ultrasound
高强度聚焦超声照射后大鼠股动脉血流和组织变性的连续变化
  • DOI:
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Tetsuya Ishikawa ,Takashi Okai,Kazuaki Sasaki,Shin-ichiro Umemura,Nozomi Miyazaki,Miki Kushima,Hiroko Aoki;Mitsuyoshi Ichihara,Kiyotake Ichizuka
  • 通讯作者:
    Mitsuyoshi Ichihara,Kiyotake Ichizuka
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OKAI Takashi其他文献

OKAI Takashi的其他文献

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{{ truncateString('OKAI Takashi', 18)}}的其他基金

Development of Noninvasive Therapeutic Devices and Clinical Techniques for Treating Uterine Fibroid by Occluding Feeding Vessels Through Exposure to High Intensity Focused Ultrasound
通过暴露于高强度聚焦超声来闭塞喂养血管治疗子宫肌瘤的无创治疗装置和临床技术的开发
  • 批准号:
    15200042
  • 财政年份:
    2003
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Differentiation of small pancreatic mass lesions by the combination of endosonography and genetic analysis of purepancreatic juice
超声内镜与纯胰液基因分析相结合鉴别胰腺小肿块病变
  • 批准号:
    08670572
  • 财政年份:
    1996
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A new combination of endoscopic ultrasonography and DNA diagnosis using pancreatic juice for the early detection of pancreatic cancer
内窥镜超声检查和胰液 DNA 诊断的新组合用于早期发现胰腺癌
  • 批准号:
    06670530
  • 财政年份:
    1994
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
A study on pathophysiology of circulatory dysfunction in immature fetuses by extrauterine fetal incubation
宫外孵化未成熟胎儿循环功能障碍的病理生理学研究
  • 批准号:
    05454344
  • 财政年份:
    1993
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Development and clinical trial of a system for three-dimensional ultrasound
三维超声系统的开发及临床试验
  • 批准号:
    03454497
  • 财政年份:
    1991
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Relationship between gastric carcinoma and intestinal metaplasia from the aspect of the expression of placental alkaline phosphatase messenger RNA
从胎盘碱性磷酸酶信使RNA表达角度探讨胃癌与肠化生的关系
  • 批准号:
    02670301
  • 财政年份:
    1990
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Development of Extrauterine Fetal Incubation System
宫外胎儿孵化系统的研制
  • 批准号:
    02557063
  • 财政年份:
    1990
  • 资助金额:
    $ 23.21万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
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