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Study of Local Regulatory Factor in Folliculogenesis and Ovulation, and Its Clinical Application

Study of Local Regulatory Factor in Folliculogenesis and Ovulation, and Its Clinical Application
卵泡发生和排卵局部调节因子的研究及其临床应用
批准号：
05454454
负责人：
OKAMURA Hitoshi
金额：
$3.97万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
项目状态：
已结题
起止时间：
1993 至 1994
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454454/
关键词：
FolliculogenesisOvulationCytokineM-CSFMacrophagePoor Responder成長因子hMG反応不良症例

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中文摘要
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英文摘要
1. The treatment with M-CFS significantly increased the number of ovulated ova compared to catrols in a dose dependent manner. This stimulatory effect of M-CFS was observed when administrered between 96h and 49h before hCG injection. Anti hM-CSF antibody significantly inhibited ovulation when administered between-24h and 3h after hCG injection. The immunohistochemical observation revealed that M-CSF increased ovarian macrophages in growing follicles.2.Serum M-CFS concentrations were gradually increased thoughout ovarian stimulation, and reached a peak at the day of oocyte retrival and two days after oocyte retrival. M-CSF concentrations in follicles were significantly higher that those in serum at the day of oocyte retrieval.3.Two cycles with clonidine-positive group were successfully induced of multiple dominant follicles, with adequate estradiol production in follicular phase and sufficient progesterone level in luteal phase.
期刊论文(14)
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会议论文
Kayoko Nishimura: "Effectiveness of Macrophage-Colony Stimulating Factor(M-CSF)on the Clonidine Positive Poor Ovarian Responders" proceeding of IV World Congress in Vitro Fertilization and Alternate Assisted Reproduction. (in press). (1995)
Kayoko Nishimura：“巨噬细胞集落刺激因子（M-CSF）对可乐定阳性卵巢反应不良者的有效性”第四届体外受精和替代辅助生殖世界大会论文集。
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通讯作者：
Kayoko Nishimura et al.: "Effect of macrophage colony-stimulating factor on folliculogenesis in gonadotrophin-primed immature rats" Journal of Reproduction and Fertility. 104. 325-330 (1995)
Kayoko Nishimura 等人：“巨噬细胞集落刺激因子对促性腺激素引发的未成熟大鼠卵泡发生的影响”《生殖与生育杂志》。
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通讯作者：
Kayoko Nishimura et al.: "Effectiveness of macrophage colony-stimulating factor(M-CSF)on the clonidine-positive poor ovarian responders" Proceeding of IX World Congress in Vitro Fertilization and Alternated Assisted Reproduction. 227-231 (1995)
Kayoko Nishimura 等人：“巨噬细胞集落刺激因子 (M-CSF) 对可乐定阳性卵巢反应不良者的有效性”第九届体外受精和交替辅助生殖世界大会论文集。
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通讯作者：
Kayoko Nishimura et al.: "Effectiveness of macrophage colony-stimulating factor (M-CSF) on the clonidine-positive poor ovarian responders" Proceeding of IX World Congress in Vitro Fertilization and Alternated Assisited Reproduction. 227-231 (1995)
Kayoko Nishimura 等人：“巨噬细胞集落刺激因子 (M-CSF) 对可乐定阳性卵巢反应不良者的有效性”第九届体外受精和交替辅助生殖世界大会论文集。
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作者： []
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共 6 条
    Epigenetics of developmental abnormality of biological rhythms
    • 批准号：
      26560460
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2014
    • 负责人：
      OKAMURA Hitoshi
    • 依托单位：
      Kyoto University
    Alternation of organ function in mice of jet-lag model
    • 批准号：
      25560426
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.5万
    • 财政年份：
      2013
    • 负责人：
      OKAMURA Hitoshi
    • 依托单位：
      Kyoto University
    Detection of circadian rhythms from peripheral blood samples in the diagnosis of diseases of elderly people
    • 批准号：
      24650217
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.5万
    • 财政年份：
      2012
    • 负责人：
      OKAMURA Hitoshi
    • 依托单位：
      Kyoto University
    SCN-Gene-Project: Molecular analysis of biological rhythms
    • 批准号：
      24240058
    • 项目类别：
      Grant-in-Aid for Scientific Research (A)
    • 资助金额：
      $30.12万
    • 财政年份：
      2012
    • 负责人：
      OKAMURA Hitoshi
    • 依托单位：
      Kyoto University
    海外基金