Molecular Clocks to Biological Rhythms

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The discovery of clock genes at 1997 and the following study of the molecular machinery of clock genes, have enabled “biological time” as a research object. We begin the present study as a project of post-cloning age. We clarified the G-protein mediated novel cellular communications in the suprachiasmatic nucleus. We synthesized an artificial transcriptional factor regulating the clock gene transcriptions. We also clarified a timing mechanism of nucleic acid metabolism in the liver, miturition rhythm in the urinary bladder, and further, we identified a novel steroid synthetic enzyme, which links between circadian clock and hypertension, in the adrenal gland.