Alternation of organ function in mice of jet-lag model

定时活动，如吃饭和睡觉，对于舒适的社交生活和健康的生活至关重要。随着生活环境的快速变化，24小时设施和熬夜的人增加了消费者的便利性和工业生产力，调节我们内部节奏的生物系统正在受到损害。通过筛选SCN中表达的多种基因的敲除，在这里我们鉴定了即使当它们突然暴露于8小时相位提前时也不显示时差反应的小鼠。我们发现SCN中加压素/V1 aV 1b受体的局部回路对时差形成至关重要。通过对慢性时差综合征的分析，我们希望阐明慢性时差综合征引起的生活方式相关疾病的机制。

Timed activities such as eating and sleeping are crucial for a comfortable social life and healthy living. As the living environment changes rapidly, and the numbers of around-the-clock facilities and people staying awake all night increase the convenience of consumers and the productivity of industries, the biological system to regulate our internal rhythms is being compromised. From screening the knockout of a variety of genes expressed in the SCN, here we identified the mice which do not show jet-lag even when they exposed suddenly to the 8-hour phase advance. We identified that the local circuits of vasopressin/V1aV1b-receptors in the SCN are crucial for jet-lag formation. From the analysis of chronic jet lag conditions, we want to clarify the mechanism of a life-style related disease evoked by chronic jet-lag.