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Construction of a system to assess and improve cognitive impairment in elderly people with dementia

评估和改善痴呆老年人认知障碍的系统构建

基本信息

批准号：
17300219
负责人：
OKAMURA Hitoshi
金额：
$ 6.59万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300219/
关键词：
cognitive function dementia speed-feedback therapy system ergometer higher brain function brain activity O_2Hb in the brain MMSE HDS-R

项目摘要

The purpose of this study was to demonstrate the efficacy in terms of the cognitive function of elderly people with dementia of a speed-feedback therapy system with a bicycle ergometer we devised, and to clarify whether the system could improve cognitive function, and neural activation in the frontal cortex played a role in improving cognitive function. The results were as follows:(1) The changes in scores on the Mini-Mental State Examination, N.type Activities of Daily Living Evaluation Scale for the Elderly, and QOL Scale for Elderly Persons with Dementia evaluation scales between before the intervention, immediately after the intervention, and 1 month after the intervention all showed significant differences between the intervention group and the control group. In addition, the attentiveness score immediately after completion of the intervention was significantly higher than before the intervention.(2) When measuring O2Hb during 40% exercise, a gradual and sustained increase in O2Hb was found, which lasted for more than 5 minutes following exercise, suggesting that dynamic exercise with a moderate intensity improve cognitive function.(3) O2Hb gradually increased in the Stroop color-word test (SCWT) and peaked 40-50s after SCWT onset, and its relative increase of O2Hb by SCWT was the same before and after exercise, suggesting that The changes of cerebral oxygen metabolism in the frontal cortex may be in association with improved cognitive function.

本研究的目的是证明我们设计的自行车测力计速度反馈治疗系统对痴呆症老年人认知功能的功效，并阐明该系统是否可以改善认知功能，以及额叶皮层的神经激活在改善认知功能中发挥作用。结果如下：(1)干预前、干预后即刻、干预后1个月简易精神状态检查、老年人日常生活活动N型评价量表、痴呆老年人生活质量评价量表评分变化均与对照组存在显着性差异。此外，干预完成后立即注意力得分明显高于干预前。(2)在40%运动中测量O2Hb时，发现O2Hb逐渐持续升高，运动后持续5分钟以上，表明中等强度的动态运动改善认知功能。(3)O2Hb在斯特鲁普色词测试(SCWT)中逐渐升高，并在运动后40-50秒达到峰值。 SCWT 的起病时间以及 SCWT 运动前后 O2Hb 的相对增加量相同，提示额叶皮层脑氧代谢的变化可能与认知功能的改善有关。