Construction of a system to assess and improve cognitive impairment in elderly people with dementia

本研究的目的是验证我们设计的带自行车测力器的速度反馈治疗系统对老年痴呆患者认知功能的疗效，并阐明该系统是否可以改善认知功能，额叶皮层的神经激活在改善认知功能中起作用。结果表明：(1)干预前、干预后、干预后1个月，干预组与对照组在《老年痴呆患者生活质量评定量表》、《老年人日常生活活动能力评定量表》、《老年痴呆患者生活质量评定量表》得分的变化均有显著性差异。此外，干预完成后立即的注意力得分显著高于干预前。(2)在40%运动时测量O2Hb，发现O2Hb逐渐持续升高，且持续5分钟以上，提示中等强度的动态运动可改善认知功能。(3)在Stroop色字测试（SCWT）中O2Hb逐渐升高，并在SCWT发作后40-50时达到峰值，且SCWT对O2Hb的相对升高与运动前后相同，提示额叶皮层脑氧代谢的改变可能与认知功能的改善有关。

The purpose of this study was to demonstrate the efficacy in terms of the cognitive function of elderly people with dementia of a speed-feedback therapy system with a bicycle ergometer we devised, and to clarify whether the system could improve cognitive function, and neural activation in the frontal cortex played a role in improving cognitive function. The results were as follows:(1) The changes in scores on the Mini-Mental State Examination, N.type Activities of Daily Living Evaluation Scale for the Elderly, and QOL Scale for Elderly Persons with Dementia evaluation scales between before the intervention, immediately after the intervention, and 1 month after the intervention all showed significant differences between the intervention group and the control group. In addition, the attentiveness score immediately after completion of the intervention was significantly higher than before the intervention.(2) When measuring O2Hb during 40% exercise, a gradual and sustained increase in O2Hb was found, which lasted for more than 5 minutes following exercise, suggesting that dynamic exercise with a moderate intensity improve cognitive function.(3) O2Hb gradually increased in the Stroop color-word test (SCWT) and peaked 40-50s after SCWT onset, and its relative increase of O2Hb by SCWT was the same before and after exercise, suggesting that The changes of cerebral oxygen metabolism in the frontal cortex may be in association with improved cognitive function.