small animal PET/CT

小动物PET/CT

• 批准号: 431798084
• 金额: --
• 依托单位: Ludwig-Maximilians-Universität München (LMU)
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/431798084?language=en
• 关键词: small; animal; PET; CT

Positron emission tomography (PET) for small animals is an important non invasive imaging modality in preclinical research. Disease course can be studied in the animal model and therapy effects can be monitored by quantification of e.g. metabolic changes. A small amount of radioactive substance is injected and the radiation is externally registered by highly sensitive detectors. Dedicated small animal PET devices can generate images with sub-millimeter spatial resolution. In addition to the development of new PET radiopharmaceuticals, research focuses on neuro-degeneration, neuro-oncology, vestibular system, and cardiology. Since the same imaging principle is applied in humans, direct translation of PET imaging protocols into the clinic is straightforward. The current PET system needs to be replaced by a state-of-the-art PET system, which is combined with an x-ray CT device, to further provide an imaging platform for various cooperating research groups.

小动物正电子发射断层扫描（PET）是一种重要的无创性影像学检查方法。可以在动物模型中研究疾病过程，并且可以通过定量例如代谢变化来监测治疗效果。注入少量的放射性物质，并通过高灵敏度探测器从外部记录辐射。专用的小动物PET设备可以生成亚毫米空间分辨率的图像。除了开发新的PET放射性药物外，研究重点还包括神经变性、神经肿瘤学、前庭系统和心脏病学。由于相同的成像原理应用于人类，因此将PET成像协议直接转化为临床是简单的。目前的PET系统需要被最先进的PET系统所取代，该系统与X射线CT设备相结合，以进一步为各种合作研究小组提供成像平台。