The Baylis-Hillman Reaction: Asymmetric Organocatalysis and Applications

Baylis-Hillman 反应：不对称有机催化及其应用

• 批准号: DP0558754
• 负责人: Dr Fei Liu
• 金额: $ 15.26万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558754
• 关键词: Baylis; Hillman; Reaction; Asymmetric; Organocatalysis

Many drugs come in two chiral mirror images (enantiomers) where the therapeutic effect is usually associated with only one while the other has no effect or can be harmful as was the case with thalidomide. Chemical reactions that yield just the desired mirror image, or enantiomer, and not the other are therefore in great demand and heavily pursued by the pharmaceutical, fine chemical and materials industries as a frontier technology. This project will result in the development of novel catalytic reactions that allow the synthesis of chiral chemicals in a cost-efficient and green manner needed by many industries, and also training of students with highly desirable synthetic skills to lead the next wave in pharmaceuticals and biotechnology.

许多药物具有两种手性镜像（对映体），其中治疗效果通常只与一种有关，而另一种没有效果或可能有害，例如沙利度胺。因此，仅产生所需镜像或对映体而不产生其他镜像或对映体的化学反应是制药、精细化工和材料工业作为一项前沿技术的巨大需求和大力追求。该项目将开发新的催化反应，使手性化学物质的合成能够以许多行业需要的低成本和绿色方式进行，并培养具有高合成技能的学生，以引领制药和生物技术的下一波浪潮。