Intimal Hyperplasia in an Atherosclerotic Model : Prevention with Low Dose Radiation

动脉粥样硬化模型中的内膜增生：低剂量辐射预防

• 批准号: 05670782
• 负责人: KOROGI Yukunori
• 金额: $ 1.34万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670782/
• 关键词: Arteries; Transluminal angioplasty; Stenosis or obstruction; Arterioscierosis; Therapeutic radiology

The usefulness of percutaneous transluminal angioplasty (PTA) for treatment of the atherosclectic occlusive lesions has been widely accepted. In spite of its high initial success rate, the restenosis remains a major problem. Restenosis after successful PTA are mainly caused by intimal hyperplasia. Proliferative smooth muscle cells play an important role in the process of intimal hyperplasia. Since proliferative cells are generally radiosensitive, radiation therapy may be useful in this issue.This experimental study was designed to investigate the effect of irradiation for prevention of intimal hyperplasia. Twenty atherosclerotic rabbits, fed with cholesterol-containing diet, were divided into four groups which were irradiated 2,5,10, and 20 Gy, respectively. The intima of both femoral arteries was performed on the unilateral side. The contralateral femoral artery served as a control. Angiograms as well as histologic specimens were obtained one month later.There were no significant differences in thickness of intimal hyperplasia beween irradiated and control sites in groups irradiated with 2 and 5 Gy. However, in a 10 Gy-irradiated group, intimal hyperplasia of the irradiated site was significantly suppressed. Medial thinning without intimal hyperplasia, which probably caused dilatation of the lumen on angiography, was observed in a 20 Gy-irradiated group. Radiation therapy may prevent intimal hyperplasia. Further investigation on the optimal dose and timing of irradiation may be needed.

经皮腔内血管成形术（PTA）治疗动脉粥样硬化闭塞性病变的有效性已被广泛接受。尽管其初始成功率很高，但再狭窄仍然是一个主要问题。PTA成功后的再狭窄主要是内膜增生所致。血管平滑肌细胞在内膜增生过程中起重要作用。由于增殖细胞通常对放射敏感，放射治疗可能是有用的，本实验旨在探讨放射预防内膜增生的效果。20只动脉粥样硬化家兔随机分为4组，分别接受2、5、10和20戈伊的照射。双侧股动脉内膜均在单侧进行。对侧股动脉作为对照。1个月后行血管造影及组织学检查，2、5戈伊照射组与对照组内膜增生厚度无显著性差异。然而，在10 Gy照射组，内膜增生的照射部位显着抑制。在20 Gy辐照组中观察到中膜变薄，无内膜增生，这可能导致血管造影管腔扩张。放射治疗可预防内膜增生。可能需要进一步研究最佳剂量和照射时间。