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Value of Dynamic Susceptibility Contrast Magnetic Resonance Imaging and Diffusion-weighted MR Imaging in the Evaluation of Brain Tumors

动态磁敏感对比磁共振成像和弥散加权磁共振成像在脑肿瘤评估中的价值

基本信息

批准号：
10670861
负责人：
KOROGI Yukunori
金额：
$ 2.05万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

The degree of tumor malignancy generally correlates to tumor grade, and the direct measurement of tumor vasculature as well as cellular density is desired. Dynamic susceptibility contrast magnetic resonance imaging (perfusion MR imaging) can provide relative cerebral blood volume and, therefore, should be reliable methods to evaluate tumor vasculature in vivo. Our first purpose was to evaluate the relationship between the ratio of maximum relative cerebral blood volume (rCBV) and histologic and angiographic vascularities of gliomas using the gradient-echo echo-planar imaging technique. We also evaluated the usefulness of rCBV maps for grading gliomas. The maximum rCBV rations of the gliomas significantly correlated with both histologic and angiographic vascularities. The maximum rCBV ratios of the glioblastomas were significantly higher than those of low-grade gliomas. Perfusion MR imaging was more useful for grading glioma than conventional magnetic resonance imaging. Tumor vessel size is extremely variable due to complex tumor angiogenesis, and the gradient-echo echo-planar imaging technique was well suited for this purpose. Next, the utility of diffusion-weighted MR imaging with echo-planar imaging technique in depicting the tumor cellularity and grading of gliomas was evaluated. Tumor cellularity, analyzed with NIH imaging software on a personal computer, was compared with the apparent diffusion coefficient (ADC). The relationship of the minimum ADC to the tumor grade was also evaluated. Tumor cellularity correlated well with the minimum ADC value of the gliomas. The minimum ADC of the high-grade gliomas was significantly higher than that of the low-grade gliomas. Diffusion-weighted MR imaging was a useful technique for assessing the tumor cellularity and grading of gliomas. These informations were not obtained with conventional magnetic resonance imaging and were useful for the diagnosis and characterization of gliomas.

肿瘤恶性程度通常与肿瘤等级相关，并且需要直接测量肿瘤脉管系统以及细胞密度。动态磁敏感对比磁共振成像（灌注MR成像）可以提供相对脑血容量，因此应该是评估体内肿瘤脉管系统的可靠方法。我们的第一个目的是使用梯度回波平面成像技术评估神经胶质瘤的最大相对脑血容量（rCBV）的比率与组织学和血管造影血管分布之间的关系。我们还评估了 rCBV 图对于神经胶质瘤分级的有用性。神经胶质瘤的最大 rCBV 比率与组织学和血管造影血管显着相关。胶质母细胞瘤的最大rCBV比率显着高于低级别胶质瘤。与传统的磁共振成像相比，灌注磁共振成像对于神经胶质瘤的分级更有用。由于复杂的肿瘤血管生成，肿瘤血管大小变化极大，梯度回波平面回波成像技术非常适合此目的。接下来，评估了弥散加权磁共振成像与平面回波成像技术在描述肿瘤细胞结构和神经胶质瘤分级方面的效用。使用个人计算机上的 NIH 成像软件分析肿瘤细胞结构，并将其与表观扩散系数 (ADC) 进行比较。还评估了最小 ADC 与肿瘤分级的关系。肿瘤细胞构成与神经胶质瘤的最小 ADC 值密切相关。高级别胶质瘤的最小ADC值显着高于低级别胶质瘤。弥散加权磁共振成像是评估肿瘤细胞结构和神经胶质瘤分级的有用技术。这些信息无法通过常规磁共振成像获得，但对于神经胶质瘤的诊断和表征很有用。