Effects of medications on chronic pancreatitis in a rat model.

药物对大鼠模型慢性胰腺炎的影响。

• 批准号: 05671044
• 负责人: SUGIYAMA Masanori
• 金额: $ 1.34万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671044/
• 关键词: chronic pancreatitis; pancreatic exocrine function; protease inhibitor; animal model

The effect of oral administration of protease inhibitor (camostat) on pancreatic morphology and exocrine function (conscious-rat model) was investigated using WBN/Kob rats with spontaneous chronic pancreatitis. In nontreated WBN/Kob rats (2 to 12 months of age), pancreatic fibrosis and parenchymal destruction compatible with human chronic pancreatitis appeared at 3 months and advanced with each month. Pancreatic secretion was markedly impaired at all ages. In WBN/Kob rats fed diets containing camostat (from 2 to 3, or from 4 to 5 months of age), the pancreas was hypertrophic but did not show any histological appearances compatible with chronic pancreatitis, and moreover, exocrine funciton was thoroughly restored with increased plasma cholecystokinin concentrations. Oral administration of protease inhibitor has both preventive and therapeutic effects on pancreatic lesions and dysfunction in an animal model of chronic pancreatitis, probably via endogenous cholecystokinin release.

使用患有自发性慢性胰腺炎的 WBN/Kob 大鼠研究口服蛋白酶抑制剂（卡莫司他）对胰腺形态和外分泌功能（清醒大鼠模型）的影响。在未经治疗的 WBN/Kob 大鼠（2 至 12 月龄）中，与人类慢性胰腺炎相一致的胰腺纤维化和实质破坏在 3 个月时出现，并且每个月都会进展。所有年龄段的胰腺分泌均明显受损。在喂食含有卡莫司他的饮食的WBN/Kob大鼠中（2至3月龄或4至5月龄），胰腺肥大，但没有表现出任何与慢性胰腺炎相一致的组织学表现，而且，随着血浆缩胆囊素浓度的增加，外分泌功能彻底恢复。口服蛋白酶抑制剂对慢性胰腺炎动物模型中的胰腺病变和功能障碍具有预防和治疗作用，可能是通过内源性缩胆囊素的释放。