Effects of medications on chronic pancreatitis in a rat model.

采用自发性慢性胰腺炎WBN/Kob大鼠，观察口服蛋白酶抑制剂（camostat）对胰腺形态和外分泌功能的影响（意识-大鼠模型）。在未治疗的WBN/Kob大鼠（2至12月龄）中，胰腺纤维化和实质破坏与人类慢性胰腺炎相一致，在3月龄时出现，并且每个月进展。胰腺分泌在各年龄段均明显受损。在WBN/Kob大鼠饲粮中添加卡莫司他（2 - 3月龄，或4 - 5月龄）时，胰腺肥厚，但没有表现出任何与慢性胰腺炎相符的组织学表现，此外，随着血浆胆囊收缩素浓度的增加，外分泌功能完全恢复。口服蛋白酶抑制剂对慢性胰腺炎动物模型的胰腺病变和功能障碍具有预防和治疗作用，可能是通过内源性胆囊收缩素释放。

The effect of oral administration of protease inhibitor (camostat) on pancreatic morphology and exocrine function (conscious-rat model) was investigated using WBN/Kob rats with spontaneous chronic pancreatitis. In nontreated WBN/Kob rats (2 to 12 months of age), pancreatic fibrosis and parenchymal destruction compatible with human chronic pancreatitis appeared at 3 months and advanced with each month. Pancreatic secretion was markedly impaired at all ages. In WBN/Kob rats fed diets containing camostat (from 2 to 3, or from 4 to 5 months of age), the pancreas was hypertrophic but did not show any histological appearances compatible with chronic pancreatitis, and moreover, exocrine funciton was thoroughly restored with increased plasma cholecystokinin concentrations. Oral administration of protease inhibitor has both preventive and therapeutic effects on pancreatic lesions and dysfunction in an animal model of chronic pancreatitis, probably via endogenous cholecystokinin release.