Effects of various drugs on pancreatic exocrine function in cerulein-induced acute pancreatitis in the rat

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We experimentally investigated effect of secretin on pancreatic exocrine function in cerulein-induced acute pancreatitis in the rat. Cholecystokinin-stimulated pancreatic secretion was examined in conscious rats after surgical preparation with external pancreatic fistula. Four days after surgical preparation, we induced acute pancreatitis by intravenous administration of cerulein at a rate of 10 mug/kg/h for 4 hours, followed by administration of normal saline (control group) or secretin (5CU/kg/h, 8 hours ; secretin group). Pancreatic exocrine function test was undertaken one day before and after cerulein administration. Microscopically, the pancreas in control group showed prominent interstitial edema and intracellular vacuolization of the acinar cell. These findings were partially improved after secretin administration. In control group, basal and cholecystokinin-stimulated pancreatic juice flow, bicarbonate output, and protein output decreased significantly after cerulein administration. Secretin reestablished pancreatic juice flow and bicarbonate output, and partially restored protein output. In rats with cerulein-induced pancreatitis, secretin reduced pancreatic histopathology and restored exocrine dysfunction, when compared with non-secretin-treated rats.