Effects of the continuous warm cardioplegic coronary perfusion on the postischemic myocardial function

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The cardioprotective effect of the calcium and magnesium content of continuous warm hyperkalemic cardioplegic solutions (CWCP) was investigated using isolated rat hearts.1. The maximum recovery of postischemic myocardial function was observed in hearts with a calcium concentration of 1.0mM regardless of magnesium concentrations.2. The recovery of postischemic myocardial function decreased in hearts with calcium concentrations of 0.5mM or less as magnesium concentration increased.3. The creatine kinase leakage in CWCP increased in hearts with calcium of 0.5mM or less as magnesium increased.These results suggest that the myocardial protective effects with the continuous warm cardioplegia depend on the relationship of calcium and magnesium concentration, which are different from the effects observed with ischemic state.