Effect of Local Administration of Extracellular Molecules on Ligament Healing

韧带损伤是一种常见的损伤，尤其是在年轻活跃的个体中。对于受伤的韧带的治疗是固定了很长一段时间，这往往会产生肌肉萎缩和关节挛缩。此外，在膝关节的十字韧带是众所周知的愈合非常差。因此促进或增强韧带愈合是矫形外科领域的基本问题之一。本研究旨在评估细胞外基质对韧带愈合的影响，以促进韧带的修复过程。首先，建立了具有良好重复性的韧带损伤模型，认为兔膝关节前交叉韧带部分切除模型适用于上述情况。随后，我们尝试了几种细胞外基质来促进韧带的愈合，实验结果表明，关节内注射透明质酸钠可以促进韧带的愈合，每次间隔一周，重复给药。考虑到透明质酸钠关节内给药在临床上是常规的，本研究的结果在临床应用中具有良好的前景。

Ligament injury is a common injury, especially among young active individuals. The treatment for the injured ligament is immobilization for a prolonged period, which often yields muscle atrophy and contractures of the joints.In addition, cruciate ligaments in the knee joints are well known to heal very poorly. therefore, promotion or enhancement of ligament healing is one of the fundamental problems in the field of orthopaedics. In this study, the effect of extracellular matrix on ligament healing was evaluated, intending to facilitate the repair processes.The experiment was performed in two stages. Firstly, appropriate ligament injury model with adequate reproducibility was developed ; we concluded partial resection model of anterior cruciate ligament in rabbit knee joint is suitable for these conditions. Subsequently, several extracellular matrix was tried to enhance ligament healing using this model.As the results of this study, intra-articular injection of hyaruronate could facilitate the healing process of the ligament, when administrated repeatedly with an interval of one week. Considering that intra-articular administration of hyaruronate is routinely performed in clinics, the results of this study has a good promise in clinical applications.