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The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.

The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.
骨关节炎分子背景和治疗靶点的综合研究:ROAD 项目。
批准号:
19109007
负责人:
NAKAMURA Kozo
金额:
$70.97万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011

项目摘要

项目成果

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中文摘要
翻译
社会对骨关节炎(OA)预防和治疗的需求日益增加。我们已经建立了ROAD项目,作为一项全面的OA研究,以阐明病因和识别治疗的分子靶点。在此,我们进行了1)克隆软骨降解的调节分子并阐明其潜在机制,2)开发OA严重程度的测量,3)全面和系统地寻找遗传和环境因素。
英文摘要
Social needs for prevention and treatment of osteoarthritis(OA) is increasing. We have established the ROAD project as a comprehensive study of OA for elucidation of the etiology and identification of the molecular target of treatment. Here we performed 1) cloning of regulatory molecules of cartilage degradation and elucidation of the underlying mechanism, 2) Development of measurement of the OA severity, 3) Comprehensive and systemic search for the genetic and environmental factors.
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会议论文
DOI: 10.1016/j.bbrc.2007.03.173
发表时间: 2007-06-15
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Ohba, Shinsuke, Nakajima, Keiji, Chung, Ung-il]
通讯作者: Chung, Ung-il
マウスジェネティクスを用いた変形性関節症の分子メカニズムの解明 (シンポジウム : 骨・軟骨疾患の分子生物学)
利用小鼠遗传学阐明骨关节炎的分子机制(研讨会:骨和软骨疾病的分子生物学)
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [酒井啓行, ツィンツァレク トビアス, 川波弘道, 猿渡洋, 鹿野清宏, 李晃伸, Okuda J, 川口浩]
通讯作者: 川口浩
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [服部高子, 他, 川口浩]
通讯作者: 川口浩
Cross-linked brush-like structure of surface-modified layers gives high durability to joint replacement
表面改性层的交联刷状结构为关节置换提供了高耐久性
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kyomoto M, Moro T, Miyaji F, Yamawaki N, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K]
通讯作者: Ishihara K
192
    Clarification of the blood pressure lowering mechanism of novel peptides identified from fermented buckwheat sprouts
    • 批准号:
      26450154
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2014
    • 负责人:
      NAKAMURA Kozo
    • 依托单位:
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    Development of Preparative Method of Deuterium and/or Heavy CarbonLabeled Phenols for Kinetic Analysis of Food Chemicals
    • 批准号:
      18688006
    • 项目类别:
      Grant-in-Aid for Young Scientists (A)
    • 资助金额:
      $11.81万
    • 财政年份:
      2006
    • 负责人:
      NAKAMURA Kozo
    • 依托单位:
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