The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.
The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.
批准号:
19109007
负责人:
NAKAMURA Kozo
金额:
$70.97万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011
中文摘要
社会对预防和治疗骨性关节炎(OA)的需求正在增加。我们已经建立了ROAD项目,作为对OA的综合研究,以阐明其病因并确定治疗的分子靶点。在这里,我们进行了1)软骨退化调节分子的克隆和潜在机制的阐明,2)骨关节炎严重程度测量的发展,3)对遗传和环境因素的全面和系统的研究。
英文摘要
Social needs for prevention and treatment of osteoarthritis(OA) is increasing. We have established the ROAD project as a comprehensive study of OA for elucidation of the etiology and identification of the molecular target of treatment. Here we performed 1) cloning of regulatory molecules of cartilage degradation and elucidation of the underlying mechanism, 2) Development of measurement of the OA severity, 3) Comprehensive and systemic search for the genetic and environmental factors.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
マウスジェネティクスを用いた変形性関節症の分子メカニズムの解明 (シンポジウム : 骨・軟骨疾患の分子生物学)
利用小鼠遗传学阐明骨关节炎的分子机制(研讨会:骨和软骨疾病的分子生物学)
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[酒井啓行, ツィンツァレク トビアス, 川波弘道, 猿渡洋, 鹿野清宏, 李晃伸, Okuda J, 川口浩]
通讯作者:
川口浩
変形性関節症の治療ガイドライン. Geriatric Medicine 老年医学 (特集 : 変形性関節症・脊椎症)-診断と治療の最前線-
老年医学治疗指南(专题:骨关节炎和脊柱病) - 诊断和治疗的最前沿 -
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[服部高子, 他, 川口浩]
通讯作者:
川口浩
関節軟骨形成遺伝子Wht9aおよびGdf5の転写制御の検討による転写因子p63の同定
通过检查关节软骨形成基因 Wht9a 和 Gdf5 的转录调控来鉴定转录因子 p63
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Shunsuke Inenaga, Kenichiro Oyama, Hiroto Yasuura, 和泉諭, 菅哲徳]
通讯作者:
菅哲徳
cDNAマイクロアレイを用いた骨肉腫の治療標的分子ROR2の同定および機能解析
骨肉瘤治疗靶分子ROR2的cDNA微阵列鉴定及功能分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kouji Kozaki, Yusuke Hayashi, Munehiko Sasajima, Shinya Tarumi, Riichiro Mizoguchi, 森岡和仁]
通讯作者:
森岡和仁
HIF-2Aは軟骨内骨化における軟骨細胞の後期分化を広く制御する転写因子である
HIF-2A 是一种转录因子,广泛控制软骨细胞在软骨内骨化过程中的晚期分化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[斎藤琢]
通讯作者:
斎藤琢
共 192 条
Clarification of the blood pressure lowering mechanism of novel peptides identified from fermented buckwheat sprouts
-
批准号:26450154
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:NAKAMURA Kozo
-
依托单位:
The effect of lipopolysaccharide preconditioning in mouse model of spinal cord injury
-
批准号:25670660
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2013
-
负责人:NAKAMURA Kozo
-
依托单位:
Development of a cumulus parameterization scheme based on a new static stability criterion
-
批准号:23540520
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:NAKAMURA Kozo
-
依托单位:
Development of Preparative Method of Deuterium and/or Heavy CarbonLabeled Phenols for Kinetic Analysis of Food Chemicals
-
批准号:18688006
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$11.81万
-
财政年份:2006
-
负责人:NAKAMURA Kozo
-
依托单位:
Research on Pathophysiology and Novel Treatment of Osteoarthritis through Molecular Biological Approach
-
批准号:15209049
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$31.7万
-
财政年份:2003
-
负责人:NAKAMURA Kozo
-
依托单位:
An experimental study on an instability of a baroclinic flow caused by a surface cooling in a rotating fluid
-
批准号:14340138
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2002
-
负责人:NAKAMURA Kozo
-
依托单位:
Involvement of the aging-suppressor gene klotho in the skeletal
-
批准号:12307031
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$22.3万
-
财政年份:2000
-
负责人:NAKAMURA Kozo
-
依托单位:
Mechanism of bone resorption by fibroblast growth factor-2
-
批准号:10470302
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.57万
-
财政年份:1998
-
负责人:NAKAMURA Kozo
-
依托单位:
Generation mechanism and prediction of near surface gusts generated by deep convection.
-
批准号:09680440
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:1997
-
负责人:NAKAMURA Kozo
-
依托单位:
Development of the system for membrane separation of fatty aicd from supereritical carbon dioxide
-
批准号:08556019
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.16万
-
财政年份:1996
-
负责人:NAKAMURA Kozo
-
依托单位:
Sterilization of Food Powder by Flash Discharge of High-Pressure Gas
-
批准号:05453168
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1993
-
负责人:NAKAMURA Kozo
-
依托单位:
Effect of Local Administration of Extracellular Molecules on Ligament Healing
-
批准号:05671202
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1993
-
负责人:NAKAMURA Kozo
-
依托单位:
Development of Membrane Separation of Supercritical Fluid
-
批准号:03555198
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$8.45万
-
财政年份:1991
-
负责人:NAKAMURA Kozo
-
依托单位:
Adsorption of High Pressure Carbon Dioxide on Food Bio-materials.
-
批准号:03660126
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1991
-
负责人:NAKAMURA Kozo
-
依托单位:
Development of Supercritical Fluid Bioreactor
-
批准号:62860012
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$6.14万
-
财政年份:1987
-
负责人:NAKAMURA Kozo
-
依托单位:
海外基金