课题基金 / 基金详情

Nitric Oxide as selective pulmonary vasodilator

Nitric Oxide as selective pulmonary vasodilator
一氧化氮作为选择性肺血管扩张剂
批准号:
05671259
负责人:
MARUYAMA Kazuo
金额:
$1.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994

项目摘要

项目成果

MARUYAMA Kazuo的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Nitric oxide (NO) released from endothelium plays an important role in regulating vascular tone. No may be released from intramural nerve endings from nonadrenergic, noncholinergic nerve and this also leads to vasodilation. In pulmonary hypertension endothelial changes and hypertropy and hyperplasia in vascular smooth muscles in the media are observed. In hypertensive pulmonary areies, endothelium-dependent relaxation induced by acetylcholine and relaxation induced by NO were impaired. This might due to desensitization of soluble guanylate cyclase in the pulmonary vasular smooth muscle, because there may be an increase in nitric oxide production in endothelium of hypertensive pulmonary arteries. Although relaxation to NO is depressed compared to control, the relaxant effect of NO is not completely abolished. In pulmonary hypertensive rats with structural remodeling inhaled NO did induced selective pulmonary vasodilatation.
期刊论文(36)
专著(0)
科研奖励(0)
会议论文
Maruyama K.Kobayashi H., Tagushi O., Chikusa H., and Muneyuki M.: "Higher doses of inhaled nitric oxide might be less effective in improving oxygenation in a patient with interstitial pulmonary fibrosis.[correspondence]" Anesth.Analg.(in press).
Maruyama K.Kobayashi H.、Tagushi O.、Chikusa H. 和 Muneyuki M.:“较高剂量的吸入一氧化氮可能在改善间质性肺纤维化患者的氧合方面效果较差。[通讯]” Anesth.Analg。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Maruyama J. et al.: "Impaired nitric oxide dependent responses and their recovery in hypertensive pulmonary orteries of rats" Am.J.Physiol.(Heart Civc.Physiol.). 266. H2476-H2488 (1994)
Maruyama J. 等人:“大鼠高血压肺动脉中一氧化氮依赖性反应受损及其恢复”Am.J.Physiol.(Heart Civc.Physiol.)。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Katayama Y.: "Effects of inhaied nitric oxide in rats with chemically induced pulmonary hypertension" Respir. Physiol.97. 301-307 (1994)
Katayama Y.:“吸入一氧化氮对化学诱导肺动脉高压大鼠的影响”Respir。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Maruyama K.: "Reduction of pulmonary Shunt by low-dose inhaled nitric oxide in a patient with late-stage respiratory distrees assoria ted with pakafoi puitor" Intensive Care Med.(in press).
Maruyama K.:“在患有与 pakafoi puitor 相关的晚期呼吸系统疾病的患者中,通过低剂量吸入一氧化氮减少肺分流”,重症监护医学(正在出版)。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
18
    Development of new bubble with fluorous chemistry
    • 批准号:
      24650299
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      MARUYAMA Kazuo
    • 依托单位:
    Ultrasound cancer therapy in next-generation with liposomal nanobubbles having both functions of diagnostics and therapeutics
    • 批准号:
      23300192
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2011
    • 负责人:
      MARUYAMA Kazuo
    • 依托单位:
    Therapeutic target for pulmonary hypertension based on coagulative and inflammatory cascade analysis
    • 批准号:
      21592003
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2009
    • 负责人:
      MARUYAMA Kazuo
    • 依托单位:
    Development of siRNA delivery system by the combination of bubble liposomes and ultrasound
    • 批准号:
      19300185
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.06万
    • 财政年份:
      2007
    • 负责人:
      MARUYAMA Kazuo
    • 依托单位: