Nitric Oxide as selective pulmonary vasodilator
Nitric Oxide as selective pulmonary vasodilator
批准号:
05671259
负责人:
MARUYAMA Kazuo
金额:
$1.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994
中文摘要
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英文摘要
Nitric oxide (NO) released from endothelium plays an important role in regulating vascular tone. No may be released from intramural nerve endings from nonadrenergic, noncholinergic nerve and this also leads to vasodilation. In pulmonary hypertension endothelial changes and hypertropy and hyperplasia in vascular smooth muscles in the media are observed. In hypertensive pulmonary areies, endothelium-dependent relaxation induced by acetylcholine and relaxation induced by NO were impaired. This might due to desensitization of soluble guanylate cyclase in the pulmonary vasular smooth muscle, because there may be an increase in nitric oxide production in endothelium of hypertensive pulmonary arteries. Although relaxation to NO is depressed compared to control, the relaxant effect of NO is not completely abolished. In pulmonary hypertensive rats with structural remodeling inhaled NO did induced selective pulmonary vasodilatation.
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Maruyama K.Kobayashi H., Tagushi O., Chikusa H., and Muneyuki M.: "Higher doses of inhaled nitric oxide might be less effective in improving oxygenation in a patient with interstitial pulmonary fibrosis.[correspondence]" Anesth.Analg.(in press).
Maruyama K.Kobayashi H.、Tagushi O.、Chikusa H. 和 Muneyuki M.:“较高剂量的吸入一氧化氮可能在改善间质性肺纤维化患者的氧合方面效果较差。[通讯]” Anesth.Analg。
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通讯作者:
Maruyama J. et al.: "Impaired nitric oxide dependent responses and their recovery in hypertensive pulmonary orteries of rats" Am.J.Physiol.(Heart Civc.Physiol.). 266. H2476-H2488 (1994)
Maruyama J. 等人:“大鼠高血压肺动脉中一氧化氮依赖性反应受损及其恢复”Am.J.Physiol.(Heart Civc.Physiol.)。
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Katayama Y.: "Effects of inhaied nitric oxide in rats with chemically induced pulmonary hypertension" Respir. Physiol.97. 301-307 (1994)
Katayama Y.:“吸入一氧化氮对化学诱导肺动脉高压大鼠的影响”Respir。
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Maruyama K.: "Reduction of pulmonary Shunt by low-dose inhaled nitric oxide in a patient with late-stage respiratory distrees assoria ted with pakafoi puitor" Intensive Care Med.(in press).
Maruyama K.:“在患有与 pakafoi puitor 相关的晚期呼吸系统疾病的患者中,通过低剂量吸入一氧化氮减少肺分流”,重症监护医学(正在出版)。
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Maruyama K., Nakai Y., Chikusa H.and Muneyuki M.: "Verapamil reduced pulmonary hypertension in abult respiratory distress syndrome." J.Anesth.8. 480-481 (1994)
Maruyama K.、Nakai Y.、Chikusa H. 和 Muneyuki M.:“维拉帕米可降低急性呼吸窘迫综合征中的肺动脉高压。”
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