Development of siRNA delivery system by the combination of bubble liposomes and ultrasound
Development of siRNA delivery system by the combination of bubble liposomes and ultrasound
批准号:
19300185
负责人:
MARUYAMA Kazuo
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
建立了泡腾型脂质体的制备方法(GMP,可控尺寸)。观察siRNA在体内外的作用效果。然而,它的效果还不足以治疗。应考虑超声条件、气泡脂质体用量等因素。针对PLK-1的siRNA治疗小鼠膀胱癌正在进行中。
英文摘要
The preparation method (GMP, controlled size) of bauble liposome was established. The effectiveness of siRNA in vitro and in vivo was observed. However, its effect was not enough for treatment. The condition of ultrasound and bubble liposome amount, etc, should be considered. Mouse bladder cancer therapy by the siRNA for PLK-1 is undergoing.
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バブルリポソームと超音波照射併用によるsiRNAの細胞内導入機構
利用气泡脂质体和超声照射将siRNA引入细胞内的机制
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[遠藤葉子, 根岸洋一, 石井和美, 鈴木亮, 丸山一雄, 新槇幸彦]
通讯作者:
新槇幸彦
超音波を利用した薬物送達におけるリポソーム技術の新展開
超声波药物递送脂质体技术的新进展
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Ryo, Suzuki, 鈴木 亮]
通讯作者:
鈴木 亮
Novel siRNA-loaded liposomal Bubbles with ultrasound exposure for RNA interference
新型装载 siRNA 的脂质体气泡,超声暴露用于 RNA 干扰
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[峯垣哲也、高良恒史, 他, Y. Endo]
通讯作者:
Y. Endo
Effective In Vitro and In Vivo Gene Delivery by The Combination of Liposomal Bubbles (Bubble liposomes) and Ultrasound Exposure, in Liposomes, Methods and Protocols (Ed by Volkmar Weissig)
通过结合脂质体气泡(气泡脂质体)和超声暴露在脂质体中有效进行体外和体内基因传递、方法和方案(Volkmar Weissig 编)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suzuki R, Maruyama K]
通讯作者:
Maruyama K
Development of minimally invasive and tissue specific gene delivery with novel liposomal bubbles
使用新型脂质体气泡开发微创和组织特异性基因递送
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Ryo, Suzuki]
通讯作者:
Suzuki
共 22 条
Development of new bubble with fluorous chemistry
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批准号:24650299
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2012
-
负责人:MARUYAMA Kazuo
-
依托单位:
Ultrasound cancer therapy in next-generation with liposomal nanobubbles having both functions of diagnostics and therapeutics
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批准号:23300192
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2011
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负责人:MARUYAMA Kazuo
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依托单位:
Therapeutic target for pulmonary hypertension based on coagulative and inflammatory cascade analysis
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批准号:21592003
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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负责人:MARUYAMA Kazuo
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依托单位:
Treatment of pulmonary hypertension by retinoid
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批准号:16390449
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.01万
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财政年份:2004
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负责人:MARUYAMA Kazuo
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依托单位:
Therapy of experimental pulmonary hypertension by cyclic GMP related gene transfer
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批准号:14370484
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.46万
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财政年份:2002
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负责人:MARUYAMA Kazuo
-
依托单位:
Development of intracellular targeting liposomes for boron neutron-capture therapy
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批准号:13470190
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2001
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负责人:MARUYAMA Kazuo
-
依托单位:
Role of Ca sensitivity in NO inhalation for pulmonary hypertension
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批准号:12470319
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.14万
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财政年份:2000
-
负责人:MARUYAMA Kazuo
-
依托单位:
Effects of nitric oxide in ion channel in hypertensive pulmonary vascular smooth muscle cells.
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批准号:09470326
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.27万
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财政年份:1997
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负责人:MARUYAMA Kazuo
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依托单位:
Development of the targetable and fusogenic polyethyleneglycol liposomes for gene delivery
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批准号:08672568
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:MARUYAMA Kazuo
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依托单位:
Effects of prolonged NO inhalation on calcium concentration in pulmonary arteries.
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批准号:07457354
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.01万
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财政年份:1995
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负责人:MARUYAMA Kazuo
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依托单位:
Study on Industrialization of Precise Non-contact Type Coordinate Measuring Machine with 5 Controlled Axs
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批准号:07505002
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$21.7万
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财政年份:1995
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负责人:MARUYAMA Kazuo
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依托单位:
Nitric Oxide as selective pulmonary vasodilator
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批准号:05671259
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1993
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负责人:MARUYAMA Kazuo
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依托单位:
Study on Form Rolling Method of High Strength FRP Screw Thread Using Ultrasonic Vibration
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批准号:05452143
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.74万
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财政年份:1993
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负责人:MARUYAMA Kazuo
-
依托单位:
Industrialization of Non-contact-type Probe for Three-coordinate Measurement
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批准号:01850036
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项目类别:Grant-in-Aid for Developmental Scientific Research (B).
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资助金额:$3.78万
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财政年份:1989
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负责人:MARUYAMA Kazuo
-
依托单位:
海外基金