THE STUDY OF THE EARLY DIAGNOSIS FOR INVOLUTIONAL OSTEOPOROSIS

更年期骨质疏松症早期诊断的研究

• 批准号: 05671572
• 负责人: TAGUCHI Akira
• 金额: $ 1.28万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671572/
• 关键词: PANORAMIC RADIOGRAPH; MANDIBLE; BONE MINERAL; MENOPAUSE; OSTEOPOROSIS; TOOTHLOSS

To diagnose the patients of postmenopausal osteoporosis as early as possible using oral signs, we investigated the relationship of the oral indicators to the mineral status of lumbar vertebra and the presence of thoracic vertebral fracture. Our results were as follow. 1.The bone mineral density (BMD) of mandibular cortex measured by quantitative computed tomography (QCT) decreased rapidly after menopause. There was significantly positive correlation between the mandibular cortical and lumbar vertebral BMD which related to the incidence of the vertebral fracture in osteoporotic women.2.The mandibular inferior cortical width (MCW) on panoramic radiograph was also highly correlated to the lumbar vertebral BMD (r=0.48, p<0.001). Especially, it was presumed that the postmenopausal women with MCW of less than 0.22cm might suffer from latent fracture of the lumber vertebra.3.There was significant difference in the number of teeth present and the degree of mandibular alveolar bone resorption between the women with and without thoracic vertebral fractures. The highly incidence of edentate was also seen in women with fracture (60%), compared to that without fractre(3%). A significant difference in the incidence of edentate between the two groups was also seen.Our results suggested that the early and/or latent posmenopausal osteoporosis can be detected by evaluating the assessment the MCW and the dental sign such as the number of teeth present.

为尽早应用口腔体征诊断绝经后骨质疏松症，本研究探讨了口腔体征与腰椎矿物质状态及胸椎骨折的关系。我们的研究结果如下。1.定量计算机断层扫描（QCT）测量的下颌骨皮质骨密度（BMD）在绝经后迅速下降。下颌骨皮质骨密度与腰椎骨密度呈显著正相关，与腰椎骨折的发生率相关。2.曲面断层片上下颌骨下皮质宽度（MCW）与腰椎骨密度也呈显著正相关（r=0.48，p<0.001）。特别是绝经后女性MCW <0.22cm者，推测可能存在腰椎潜在骨折。3.胸椎骨折组与非胸椎骨折组的牙齿数目及下颌骨吸收程度有显著性差异。骨折组缺齿发生率为60%，而无骨折组为3%。两组间缺牙发生率也有显著性差异，提示通过MCW和牙齿体征如牙齿数的评估，可以发现早期和/或潜在的绝经后骨质疏松症。

项目成果

Akira Taguchi: "The estimation of the radiomorphometric indices of the mandible using panoramic radiography." Oral Radiol. 33. 309-316 (1993)

Akira Taguchi：“使用全景放射线照相术估计下颌骨的放射形态测量指数。”

田口 明: "回転パノラマX線写真による閉経後骨粗鬆症診断の試み" 日本骨形態計測学会雑誌. 4. 113-118 (1994)

Akira Taguchi：“尝试使用旋转全景 X 线照片诊断绝经后骨质疏松症”，日本骨形态测量学会杂志，4. 113-118 (1994)。

Taguchi A: "Tooth loss and mandibular osteopenia" Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 78. 127-132 (1995)

田口 A：“牙齿缺失和下颌骨质减少” Oral Surg Oral Med Oral Pathol Oral Radiol Endod。

田口 明: "パノラマX線写真における顎骨骨量の指標とその評価" 歯科放射線. 33. 1-8 (1993)

Akira Taguchi：“全景射线照片中下颌骨量的指标及其评估”《牙科放射学》33. 1-8 (1993)。

Akira Taguchi: "Tooth loss and mandibular osteopenia" Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 78. 127-132 (1995)

Akira Taguchi：“牙齿缺失和下颌骨质减少” Oral Surg Oral Med Oral Pathol Oral Radiol Endod。