Automatic diagnostic system for identifying individuals with osteoporosis on panoramic radiographs

通过全景X光片识别骨质疏松症患者的自动诊断系统

• 批准号: 14571786
• 负责人: TAGUCHI Akira
• 金额: $ 1.66万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571786/
• 关键词: osteoporosis; screening; menopause; women; panoramic radiographs; bone mineral density; 早期診断; 自動支援

Recent studies suggest mandibular inferior cortical shape on dental panoramic radiographs may be the useful indicator for the identification of individuals with osteoporosis. However, the diagnostic performances of this index largely depend on the experience of observers because the classification of cortical shape on panoramic radiographs is determined subjectively. In order to diagnose the cortical shape objectively, we developed computer-aided diagnosis (CAD) system that automatically can determine the classification of cortical shape on panoramic radiographs. Two hundred panoramic radiographs of postmenopausal women who had bone mineral density (BMD) assessment at the lumbar spine and the femoral neck by dual energy x-ray absorptiometry were used for this purpose. CAD system was constructed by mathematical morphology. One hundred panoramic radiographs were used for the development of CAD system in order to identify women with low BMD, and another 100 panoramic radiographs were used to estimate the validation of CAD system. Low skeletal BMD was defined as a BMD T score of -1.0 or less. The sensitivity, specificity, predictive values, and accuracy of CAD for the identification of low skeletal BMD were calculated in dichotomous 2 by 2 tables. The likelihood ratio for a positive risk index was also calculated. The sensitivity and specificity were 73.8% (95% CI, 63.1 to 84.5%) and 68.6% (95% CI, 53.2 to 84.0%), respectively, when BMD of the lumbar spine was used as a standard. Those were 66.2% (95% CI, 54.9 to 77.4%) and 56.7% (95% CI, 38.9 to 74.4%), respectively, when BMD of the femoral neck was used as a standard. The likelihood ratio was 2.35 (95% CI, 1.41 to 3.91) at the lumbar spine and 1.53 (95% CI, 0.98 to 2.38) at the femoral neck, respectively. These results suggest CAD system applied for panoramic radiographs may be useful for the identification of low skeletal BMD

最近的研究表明，牙科全景X光片上的下颌下皮质形状可能是识别骨质疏松症患者的有用指标。然而，该指标的诊断性能很大程度上取决于观察者的经验，因为全景X线照片上皮质形状的分类是主观确定的。为了客观地诊断皮质形状，我们开发了计算机辅助诊断（CAD）系统，可以自动确定全景X线照片上皮质形状的分类。为此目的，使用了 200 张绝经后妇女的全景 X 光片，这些妇女通过双能 X 射线吸收测定法对腰椎和股骨颈进行了骨矿物质密度 (BMD) 评估。利用数学形态学构建了CAD系统。使用一百张全景X光照片来开发CAD系统，以识别骨密度低的女性，并使用另外100张全景X光照片来评估CAD系统的验证。低骨骼 BMD 被定义为 BMD T 分数为 -1.0 或更低。 CAD 识别低骨骼 BMD 的敏感性、特异性、预测值和准确性在二分 2 × 2 表中计算。还计算了正风险指数的似然比。当以腰椎 BMD 作为标准时，敏感性和特异性分别为 73.8%（95% CI，63.1 至 84.5%）和 68.6%（95% CI，53.2 至 84.0%）。当以股骨颈 BMD 为标准时，这一比例分别为 66.2%（95% CI，54.9%～77.4%）和 56.7%（95% CI，38.9%～74.4%）。腰椎的似然比为 2.35（95% CI，1.41 至 3.91），股骨颈的似然比为 1.53（95% CI，0.98 至 2.38）。这些结果表明应用于全景 X 线照片的 CAD 系统可能有助于识别低骨骼 BMD

项目成果

Akira Taguchi: "Detection of vascular disease risk in women by panoramic radiograph"Journal of Dental Research. 82. 838-843 (2003)

Akira Taguchi：“通过全景X光检查女性血管疾病风险”《牙科研究杂志》。

Akira Taguchi: "Relationship between dental panoramic radiographic findings and biochemical markers of bone turnover"Journal of Bone Mineral Research. 18. 1689-1694 (2003)

Akira Taguchi：“牙科全景X光检查结果与骨转换生化标志物之间的关系”骨矿物质研究杂志。

Akira Taguchi: "Association of estrogen and vitamin D receptor gene polymorphisms with tooth loss and oral bone loss in Japanese postmenopausal women"Menopause. 10. 250-257 (2003)

Akira Taguchi：“雌激素和维生素 D 受体基因多态性与日本绝经后妇女牙齿脱落和口腔骨质流失的关联”。

Taguchi A. et al.: "Association of estrogen and vitamin D receptor gene polymorphisms with tooth loss and oral bone loss in Japanese postmenopausal women"Menopause-The Journal of the North America Menopause Society. (In press). (2003)

Taguchi A. 等人：“雌激素和维生素 D 受体基因多态性与日本绝经后妇女牙齿脱落和口腔骨质流失的关联”更年期 - 北美更年期协会杂志。

Taguchi A. et al.: "Relationship between dental panoramic radiographic findings and biochemical markers of bone turnover"Journal of Bone and Mineral Research. (In press). (2003)

Taguchi A. 等人：“牙科全景放射线检查结果与骨转换生化标志物之间的关系”《骨与矿物质研究杂志》。