Die Rolle des IKK/NF-kappaB Signaltransduktionswegs für die Regulation der Haut-Homöostase und Barrierefunktion in epidermalen Keratinozyten

IKK/NF-κB信号转导通路在表皮角质形成细胞皮肤稳态和屏障功能调节中的作用

• 批准号: 43639396
• 负责人: Professor Dr. Manolis Pasparakis
• 金额: --
• 依托单位: Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/43639396?language=en
• 关键词: Die; Rolle; des; IKK; NF

The IKK/NF-κB signalling pathway regulates cellular responses to infection, inflammation and stress. In the epidermis, IKK subunits display differential functions. IKK1 is required for keratinocyte differentiation and formation of a stratified epidermis. In contrast, IKK2 and NEMO are not needed for epidermal development, but play a crucial role in the regulation of the immune homeostasis in the skin. In the context of this project proposal, we aim to investigate the cellular and molecular mechanisms by which IKK1, IKK2 and NEMO mediate their differential functions in epidermal keratinocytes. For these studies we are using conditional targeting of IKK1, IKK2 and NEMO in mice.

IKK/NF-κB信号通路调节细胞对感染、炎症和应激的反应。在表皮中，IKK亚基显示不同的功能。IKK 1是角质形成细胞分化和形成复层表皮所必需的。相比之下，IKK 2和NEMO不是表皮发育所必需的，但在皮肤免疫稳态的调节中起着至关重要的作用。在本项目的背景下，我们的目标是研究IKK 1，IKK 2和NEMO介导其在表皮角质形成细胞中的差异功能的细胞和分子机制。对于这些研究，我们在小鼠中使用IKK 1、IKK 2和NEMO的条件性靶向。