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Studies on the combination therapy of radiofrequency capacitive heating and interstitial heating for malignant brain tumor.

射频电容加热与间质加热联合治疗恶性脑肿瘤的研究

基本信息

批准号：
60480326
负责人：
TANAKA Ryuichi
金额：
$ 3.78万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480326/
关键词：
Hyperthermia Interstitial heating Extracranial capacitive heating Radiofrequency アプリケーター

项目摘要

To faciliate the effects of radiofrequency (RF) capacitive heating on malignant brain tumor, a new interstitial heating system was developed and the significance and the possibility of the combination therapy of hyperthermia using RF capacitive and interstitial heating was evaluated.For interstitial heating, we chose RF instead of microwave, for the reason that microwave could not penetrate into the deep region beyond 10 mm in our phantom study and that the minimal diameter of the microwave applicator was 3 mm and too big to be inserted into the brain. We designed various types of needle type RF applicators. The multible needle applicators made of flexible wire made it possible to heat accurately and safely the optional and well-localized areas of the brain.For further evaluation of the RF capacitive heating system which we had already developed, we proceeded to the clinical application of this system. Fifteen patients with glioblastoma were treated by extracranial heating method safely. However, the deep region of the brain was heated insufficiently and remained 40 - 42゜C.There is no technical problem in the clinical application of our newly developed interstitial heating system and this new system could cover the weak points of the RF capacitive heating system.

为了促进射频（RF）容性加热对恶性脑肿瘤的作用，开发了一种新的间质加热系统，并评估了射频容性和间质加热联合治疗热疗的意义和可能性。对于间隙加热，我们选择射频而不是微波，因为在我们的幻影研究中，微波无法穿透超过10mm的深层区域，并且微波涂抹器的最小直径为3mm，太大而无法插入大脑。我们设计了各种类型的针型射频应用器。由柔软的金属丝制成的多针涂抹器可以准确安全地加热大脑的可选和定位良好的区域。为了进一步评估我们已经开发的射频电容加热系统，我们开始了该系统的临床应用。采用颅外加热法对15例胶质母细胞瘤患者进行了安全治疗。然而，大脑深部区域加热不足，保持在40 - 42 C。本发明的间隙加热系统在临床应用中没有技术问题，可以弥补射频电容式加热系统的不足。