DEVELOPMENT OF COMPUTER TEMPERATURESIMULATION FOR RFINETRSTITIAL HYPERTHERMIA

近十年来，多个机构以不同的方法开展了对恶性脑肿瘤患者的热疗。采用微波、稀土天线和植入体加热的组织间热疗不同于电容式热疗，是一种方便的加热方法。目前所有方法仍处于I、II期研究阶段。我所研制的针型敷贴器射频间质热疗(RE天线)是在立体定向手术的基础上，通过天线的放射状导管，用热敏电阻探头测量温度。体表温度传感器获得的是二维的温度分布，掌握二维或三维的温度分布对于安全、有效的热疗具有重要意义。在本研究中，我们用二维有限元方法分析了热疗过程中的热分布，并讨论了计算机模拟作为治疗计划的有效性。首先，我们使用Workstation(C)建立了二维有限元计算机模拟系统。第二年，我们测量了热疗过程中的温度数据和热性质，特别是热清除率的F值。我们还研制了配备自动调谐和温度限制系统的新一代RE，并进行了I-II期临床试验，最后，从临床病例中获得可靠热物性的新研制的计算机模拟系统实际运行。我们在3例恶性胶质瘤的热疗中进行了真正可靠的计算机模拟。然而，有2例患者进行了SPECT(单光子发射CT)检查，以获得脑血流量的信息，我们当时无法报告它们和完善版本的模拟系统。我们希望在下一次达到我们的最终目的。

Hyperthermia for the patients with malignant brain tumor has been developed at multiple institute with different methods in this decade. Interstitial hyperthermia with microwave, RE antenna and implant heating is different from the capacitive hyperthermia and is a convenient method of heating. All methods are now still phase I or II studies.RF interstitial hyperthermia with needle type applicator (RE antenna) which has been developed in our institute was performed by stereotactic surgery measuring the temperature with thermistor probe through the radial catheter from the antenna. Thermal profile were obtained two dimensionally by intracatheter themosensor.It's important for safe and effective hyperthermia to graspthe temperature distribution two or three dimensionally. In this study, we have analyzed the thermal distribution during hyperthermia with two dimensional finite elements method and discussed the efficacy of the computer simulation as a treatment planning.First, we established the computer simulation system with two dimensional finite elements method using Workstation(c).The second year, we measured the temperature data and the thermal properties, especially F value of the thermal clearance rate. Then we have also developed newly RE generaot which was equippedwith automatic tuning and temperature limitation system and have examined it clinically as a phase I - II study.Finally, newly developed computer simulation system with the reliable thermal properties which were obtained from the clinical cases was moving actually. We experienced the really reliable computer simulation in 3 cases with malignant glioma treated with hyperthermia. However, there were 2 cases examined with SPECT (single photon emission CT) to get the information of cerebral blood flow volume, we were not able to report them and the perfect version of simulation system in this time. We hope to achieve our final purpose in next time.