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Development of RF interstitial capacitive hyperthermic system for malignant brain tumor.

恶性脑肿瘤射频间质电容热疗系统的研制。

基本信息

批准号：
06557077
负责人：
TANAKA Ryuichi
金额：
$ 4.22万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557077/
关键词：
Brain tumor Hyperthermia Radiofrequency Interstitial hyperthermia radiofreguency

项目摘要

In order to establish the hyperthermic system of RF interstitial capacitive heating, we studied development of RF antennas, operative technique for implant and clinical appling. A Pase I/II clinical trial has been initiated to determined the feasibility of an interstitial hyperthermia using 13.56MHz radiofrequency (RF) antennas in the treatment of malignant brain tumors. The needle type applicator (RF antennas) with diameter of 1.0mm was developed. A single or multiple (2-4) antennas were inserted into the brain tumor using a CT-guided stereotactic apparatus. The temperature of the brain and the tumor were monitored by the copper-constantan thermocouple sensors. The RF interstitial hyperthermia was performed on 30 patients with malignant brain tumors, 22 malignant gliomas (10 primary and 12 recurrent), 7 metastatic tumor and 1 malignant lymphoma. The rim of the tumors which were defined by contrast enhanced CT was heated at 43.0ﾟC for 60 minutes. The heating was repeated 3-9 (mean 5) times, once or twice a week, combined with conventional radiation or chemotherapy. The recurrent gliomas were treated with heat alone. The patients complained no local pain or heat sensation and well tolerated the repeated heating. No major complication occurred except liquorrhea in 2 cases, subcutaneous infection in one case, intratumoral hemorrhage in one case and trasient neurological symptoms in 2 cases. The anti-tumor effects were evaluated by CT and the treated tumors showd CR in 8, PR in 10, ST in 9 and PD in 3 cases, respectivery. In most of CR cases, the perifocal low density lesion also disappeared. These preliminary results indicated that the RF interstitial hyperthermia seemed to be effective in treatment of malignant brain tumors, this technique is less invasive and the tumors in aged or poor risk patients as well as deep-seated tumors can be good candidates for the application.

为了建立射频间隙式电容加热热系统，对射频天线的发展、植入的操作技术和临床应用进行了研究。一项I/II期临床试验已经启动，以确定使用13.56MHz射频（RF）天线进行间质性热疗治疗恶性脑肿瘤的可行性。研制了直径为1.0mm的针型施药器（射频天线）。使用ct引导的立体定向装置将单个或多个（2-4个）天线插入脑肿瘤。大脑和肿瘤的温度由铜-康铜热电偶传感器监测。应用射频间质热疗治疗恶性脑肿瘤30例，恶性胶质瘤22例（原发10例，复发12例），转移瘤7例，恶性淋巴瘤1例。在43.0℃温度下加热肿瘤边缘60分钟。加热3 ~ 9次（平均5次），每周1 ~ 2次，结合常规放疗或化疗。复发性胶质瘤单热治疗。患者无局部疼痛或热感觉，对反复加热耐受良好。除2例出现漏液、1例皮下感染、1例肿瘤内出血、2例出现一过性神经系统症状外，无其他重大并发症发生。CT观察抗肿瘤效果，治疗后肿瘤CR 8例，PR 10例，ST 9例，PD 3例。在大多数CR病例中，病灶周围低密度病变也消失。这些初步结果表明射频间质热疗在恶性脑肿瘤的治疗中似乎是有效的，该技术的侵入性较小，在老年或低风险患者的肿瘤以及深部肿瘤中可以很好地应用。