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Development of RF interstitial capacitive hyperthermic system for malignant brain tumor.

恶性脑肿瘤射频间质电容热疗系统的研制。

基本信息

批准号：
06557077
负责人：
TANAKA Ryuichi
金额：
$ 4.22万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557077/
关键词：
Brain tumor Hyperthermia Radiofrequency Interstitial hyperthermia radiofreguency

项目摘要

In order to establish the hyperthermic system of RF interstitial capacitive heating, we studied development of RF antennas, operative technique for implant and clinical appling. A Pase I/II clinical trial has been initiated to determined the feasibility of an interstitial hyperthermia using 13.56MHz radiofrequency (RF) antennas in the treatment of malignant brain tumors. The needle type applicator (RF antennas) with diameter of 1.0mm was developed. A single or multiple (2-4) antennas were inserted into the brain tumor using a CT-guided stereotactic apparatus. The temperature of the brain and the tumor were monitored by the copper-constantan thermocouple sensors. The RF interstitial hyperthermia was performed on 30 patients with malignant brain tumors, 22 malignant gliomas (10 primary and 12 recurrent), 7 metastatic tumor and 1 malignant lymphoma. The rim of the tumors which were defined by contrast enhanced CT was heated at 43.0ﾟC for 60 minutes. The heating was repeated 3-9 (mean 5) times, once or twice a week, combined with conventional radiation or chemotherapy. The recurrent gliomas were treated with heat alone. The patients complained no local pain or heat sensation and well tolerated the repeated heating. No major complication occurred except liquorrhea in 2 cases, subcutaneous infection in one case, intratumoral hemorrhage in one case and trasient neurological symptoms in 2 cases. The anti-tumor effects were evaluated by CT and the treated tumors showd CR in 8, PR in 10, ST in 9 and PD in 3 cases, respectivery. In most of CR cases, the perifocal low density lesion also disappeared. These preliminary results indicated that the RF interstitial hyperthermia seemed to be effective in treatment of malignant brain tumors, this technique is less invasive and the tumors in aged or poor risk patients as well as deep-seated tumors can be good candidates for the application.

为了建立射频间质电容加热热疗系统，我们对射频天线的研制、植入手术技术及临床应用进行了研究。已启动 Pase I/II 临床试验，以确定使用 13.56MHz 射频 (RF) 天线进行间质热疗治疗恶性脑肿瘤的可行性。开发出直径1.0mm的针型涂抹器（射频天线）。使用 CT 引导的立体定向装置将单个或多个 (2-4) 天线插入脑肿瘤中。通过铜-康铜热电偶传感器监测大脑和肿瘤的温度。对30例恶性脑肿瘤、22例恶性胶质瘤（10例原发性和12例复发性）、7例转移性肿瘤和1例恶性淋巴瘤患者进行了射频间质热疗。通过增强 CT 确定的肿瘤边缘在 43.0°C 下加热 60 分钟。加热重复3-9次（平均5次），每周一次或两次，并结合常规放疗或化疗。复发性神经胶质瘤仅采用热治疗。患者没有抱怨局部疼痛或热感，并且对反复加热的耐受性良好。除白酒2例、皮下感染1例、瘤内出血1例、短暂性神经症状2例外，未发生主要并发症。通过CT评价抗肿瘤效果，治疗后肿瘤分别获得CR 8例、PR 10例、ST 9例、PD 3例。在大多数 CR 病例中，灶周低密度病灶也消失了。这些初步结果表明，射频间质热疗似乎对治疗恶性脑肿瘤有效，该技术侵入性较小，老年或低风险患者的肿瘤以及深部肿瘤都可以很好地应用。