Development of RF interstitial capacitive hyperthermic system for malignant brain tumor.
恶性脑肿瘤射频间质电容热疗系统的研制。
基本信息
- 批准号:06557077
- 负责人:
- 金额:$ 4.22万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Developmental Scientific Research (B)
- 财政年份:1994
- 资助国家:日本
- 起止时间:1994 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to establish the hyperthermic system of RF interstitial capacitive heating, we studied development of RF antennas, operative technique for implant and clinical appling. A Pase I/II clinical trial has been initiated to determined the feasibility of an interstitial hyperthermia using 13.56MHz radiofrequency (RF) antennas in the treatment of malignant brain tumors. The needle type applicator (RF antennas) with diameter of 1.0mm was developed. A single or multiple (2-4) antennas were inserted into the brain tumor using a CT-guided stereotactic apparatus. The temperature of the brain and the tumor were monitored by the copper-constantan thermocouple sensors. The RF interstitial hyperthermia was performed on 30 patients with malignant brain tumors, 22 malignant gliomas (10 primary and 12 recurrent), 7 metastatic tumor and 1 malignant lymphoma. The rim of the tumors which were defined by contrast enhanced CT was heated at 43.0゚C for 60 minutes. The heating was repeated 3-9 (mean 5) times, once or twice a week, combined with conventional radiation or chemotherapy. The recurrent gliomas were treated with heat alone. The patients complained no local pain or heat sensation and well tolerated the repeated heating. No major complication occurred except liquorrhea in 2 cases, subcutaneous infection in one case, intratumoral hemorrhage in one case and trasient neurological symptoms in 2 cases. The anti-tumor effects were evaluated by CT and the treated tumors showd CR in 8, PR in 10, ST in 9 and PD in 3 cases, respectivery. In most of CR cases, the perifocal low density lesion also disappeared. These preliminary results indicated that the RF interstitial hyperthermia seemed to be effective in treatment of malignant brain tumors, this technique is less invasive and the tumors in aged or poor risk patients as well as deep-seated tumors can be good candidates for the application.
为了建立射频间隙式电容加热热系统,对射频天线的发展、植入的操作技术和临床应用进行了研究。一项I/II期临床试验已经启动,以确定使用13.56MHz射频(RF)天线进行间质性热疗治疗恶性脑肿瘤的可行性。研制了直径为1.0mm的针型施药器(射频天线)。使用ct引导的立体定向装置将单个或多个(2-4个)天线插入脑肿瘤。大脑和肿瘤的温度由铜-康铜热电偶传感器监测。应用射频间质热疗治疗恶性脑肿瘤30例,恶性胶质瘤22例(原发10例,复发12例),转移瘤7例,恶性淋巴瘤1例。在43.0℃温度下加热肿瘤边缘60分钟。加热3 ~ 9次(平均5次),每周1 ~ 2次,结合常规放疗或化疗。复发性胶质瘤单热治疗。患者无局部疼痛或热感觉,对反复加热耐受良好。除2例出现漏液、1例皮下感染、1例肿瘤内出血、2例出现一过性神经系统症状外,无其他重大并发症发生。CT观察抗肿瘤效果,治疗后肿瘤CR 8例,PR 10例,ST 9例,PD 3例。在大多数CR病例中,病灶周围低密度病变也消失。这些初步结果表明射频间质热疗在恶性脑肿瘤的治疗中似乎是有效的,该技术的侵入性较小,在老年或低风险患者的肿瘤以及深部肿瘤中可以很好地应用。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
田中隆一: "脳腫瘍-RF外部加温とRF組織内加温-" 医学のあゆみ. 168. 24-29 (1994)
Ryuichi Tanaka:“脑肿瘤 - 射频外部加热和射频组织变暖 -”医学史 168. 24-29 (1994)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
高橋英明: "悪性脳腫瘍の組織内温熱療法-RF加温による臨床成績-" 日本ハイパーサーミア学会誌. 11. 61-67 (1995)
Hideaki Takahashi:“恶性脑肿瘤的组织热疗 - 射频加热的临床结果”日本热疗学会杂志 11. 61-67 (1995)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
高橋英明: "脳腫瘍に対する温熱治療のための温度分布シミュレーション-二次元有限要素解析によるcomputer simulation-" 日本ハイパーサーミア学会誌. 11. 356-364 (1995)
Hideaki Takahashi:“脑肿瘤热治疗的温度分布模拟 - 使用二维有限元分析的计算机模拟”日本热疗学会杂志 11. 356-364 (1995)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
高橋英明: "脳腫瘍の新しい治療法、温熱療法" CLINICAL NEUROSCIENCE. 12. 657-659 (1994)
Hideaki Takahashi:“热疗法,脑肿瘤的新疗法”《临床神经科学》12. 657-659 (1994)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takahashi H., Tanaka R., et al: "Clinical results of RF interstitial hyperthermia for malignant brain tumors." Jpn.J.Hyperthermic Oncol.11. 61-67 (1995)
Takahashi H.、Tanaka R. 等人:“射频间质热疗治疗恶性脑肿瘤的临床结果。”
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TANAKA Ryuichi其他文献
TANAKA Ryuichi的其他文献
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{{ truncateString('TANAKA Ryuichi', 18)}}的其他基金
On the Relationship between Human Resource Allocation and Macroeconomic Productivity : An Educational Economic Approach
论人力资源配置与宏观经济生产率的关系:一种教育经济学方法
- 批准号:
20730128 - 财政年份:2008
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$ 4.22万 - 项目类别:
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Trial of novel thermo-gene therapy for malignant brain tumors-Aiming for enhancement of hyperthermia using p53 introduction-
恶性脑肿瘤新型热基因疗法的试验-利用p53导入增强热疗效果-
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15390430 - 财政年份:2003
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$ 4.22万 - 项目类别:
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Investigation of noninvasive heating system using re-entrant type applicator for malignant brain tumor
使用可再入式涂抹器的无创加热系统治疗恶性脑肿瘤的研究
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13557115 - 财政年份:2001
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Development of novel heat-induced cytokine gene therapy against malignant gliomas
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12470286 - 财政年份:2000
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09557115 - 财政年份:1997
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射频热疗计算机温度模拟的研制
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08457358 - 财政年份:1996
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$ 4.22万 - 项目类别:
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40゚CC热敏脂质体治疗恶性脑肿瘤的新型化疗热疗法
- 批准号:
08557081 - 财政年份:1996
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$ 4.22万 - 项目类别:
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05454394 - 财政年份:1993
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IMMUNOLOGICAL ANALYSIS OF THE RATS WITH ANTERIOR HYPOTHALAMIC LESIONS
下丘脑前部病变大鼠的免疫学分析
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02454335 - 财政年份:1990
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CULTURE OF CEREBRAL MICROVASCULAR ENDOTHELIAL CELL AND APPLICATION FOR THE ANALYSIS OF THE CEREBRAL ISCHEMIA
脑微血管内皮细胞的培养及其在脑缺血分析中的应用
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63480326 - 财政年份:1988
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$ 4.22万 - 项目类别:
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加热治癌(HYPERTHERMIA)中体内功率场分布的研究
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