Investigation of noninvasive heating system using re-entrant type applicator for malignant brain tumor

使用可再入式涂抹器的无创加热系统治疗恶性脑肿瘤的研究

• 批准号: 13557115
• 负责人: TANAKA Ryuichi
• 金额: $ 3.07万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557115/
• 关键词: re-entrant type applicator; hyperthermia; noninvasive therapy; computer simulation; malignant brain tumor; リエントラント型空洞共振器

In order to reduce invasiveness of thermotherapy for malignant brain tumors, we have been investigating heating techniques using a re-entrant type applicator, which is a noninvasive heating apparatus.In 2001, we conducted experiments to control the extent of heating. By making some improvements to the trial apparatus and changing the diameter of the re-entrant area, we were able to confirm that the extent of heating can be controlled to a maximum of about 80% of the heated tissue.In 2002, while aiming for clinical use, a round window for inserting patients was placed on the lateral side of the re-entrant type applicator with a diameter of 120 cm and height of 120 cm that had been developed for research use. Initially, using three-dimensional computer simulation, we confirmed that electric field leakage to the outside area was below the allowance. We then measured electric field leakage using a phantom. We were able to confirm that the electric field was within the allowance at least 50 … More cm away from the window. This finding was presented at The 19th Annual Meeting of the Japanese Society of Hyperthermic Oncology.Furthermore, a phantom in the shape of a human body was heated, and the distribution of temperature was measured by infrared thermography. When thermotherapy was conducted at 30 W for 15 minutes, the temperature at the core of the phantom increased by 4.5 degrees, while that at the surrounding area was less than 2 degrees, and no problematic hot spot was seen. This finding was presented at The Annual Meeting of Denshi-johotsushin at Shinetsushibu.In an animal study, a beagle was inserted through the round window on the side of the re-entrant type applicator. Electric field leakage was also below the allowance at least 50 cm away from the window.If re-entrant type thermotherapy is applied clinically, thermotherapy can be repeatedly performed in a noninvasive manner, thus increasing the efficacy of thermotherapy. Noninvasive thermotherapy in the head region using a re-entrant type applicator appears to be promising, and it should be clinically useful. Less

为了减少恶性脑肿瘤热疗的侵入性，我们一直在研究使用一种无创加热装置--再入式加热器的加热技术，并于2001年进行了控制加热程度的实验。通过对试验装置进行一些改进，并改变凹入区域的直径，我们能够确认加热的程度可以控制在最大约80%的加热组织。用于插入患者的圆形窗口被放置在该区域的外侧，直径120厘米、高120厘米的入门型施药器已开发用于研究。最初，使用三维计算机模拟，我们确认，电场泄漏到外部区域低于允许值。然后，我们使用体模测量电场泄漏。我们能够确认电场在允许范围内至少50 ...更多信息 离窗户一厘米远。在第19届日本肿瘤热疗学会年会上发表了这一发现。此外，对人体形状的体模进行加热，通过红外线热成像仪测量温度分布。当以30 W进行热疗15分钟时，体模核心温度升高4.5度，而周围区域的温度升高小于2度，未观察到有问题的热点。这一发现在Shinetsushibu举行的电子商务年会上发表。在一项动物研究中，将一只比格犬从凹进式施源器侧面的圆窗插入。如果临床应用折返式热疗，可以无创地重复进行热疗，从而提高热疗的疗效。头部区域的非侵入性热疗，使用一个再入型的喷头似乎是有前途的，它应该是临床上有用的。少

项目成果

市田 隆文: "肝移植のup to date [3]肝移植の適応 4)肝細胞癌"肝・胆・膵フロンティア. 12. 23-27 (2001)

Takafumi Ichida：“肝移植的最新进展 [3] 肝移植的适应症 4) 肝细胞癌” 肝脏/胆道/胰腺前沿 (Liver/Biliary/Pancreatic Frontier)。

Yoshinobu Sato: "Preoperative administration of 5-FU and Interferon β may prevent recurrence of hepatitis B and Cvirus"The Animal Journal of Gastroenterology. 97(1). 215-216 (2002)

Yoshinobu Sato：“术前给予 5-FU 和干扰素 β 可以预防乙型肝炎和病毒的复发”The Animal Journal of Gastroenterology 97(1) (2002)。

K. Morita, R. Tanaka et al.: "Combination therapy of rat brain tumors using localized interstitial hyperthermia and intra-arterial chemotherapy"Int J Hyperthermia. 19・2. 204-212 (2003)

K. Morita、R. Tanaka 等：“使用局部间质热疗和动脉内化疗联合治疗大鼠脑肿瘤” Int J Hyperthermia 19・2 (2003)。

Kato K, Matsuda J et al.: "Stray electromagnetic fields of a re-entrant type resonant cauit applicator for non-invasive and deep heating with a window"Jpn J Hyperthermic Oncol. 18. 168 (2002)

Kato K、Matsuda J 等人：“用于带窗口的非侵入性深度加热的可重入型共振导管涂抹器的杂散电磁场”Jpn J Hyperthermic Oncol。

Yoshinobu Sato: "Microcchimenism of donor type CDSE^+CDE^ cells in donor specific transfusion via portal vein following living related donor liver transplantation"Hepato-Gastroenterology. 43(in press). (2002)

Yoshinobu Sato：“活体相关供体肝移植后通过门静脉供体特异性输血中供体类型 CDSE^ CDE^ 细胞的微现象”肝胃肠病学。