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Investigation of noninvasive heating system using re-entrant type applicator for malignant brain tumor

使用可再入式涂抹器的无创加热系统治疗恶性脑肿瘤的研究

基本信息

批准号：
13557115
负责人：
TANAKA Ryuichi
金额：
$ 3.07万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

In order to reduce invasiveness of thermotherapy for malignant brain tumors, we have been investigating heating techniques using a re-entrant type applicator, which is a noninvasive heating apparatus.In 2001, we conducted experiments to control the extent of heating. By making some improvements to the trial apparatus and changing the diameter of the re-entrant area, we were able to confirm that the extent of heating can be controlled to a maximum of about 80% of the heated tissue.In 2002, while aiming for clinical use, a round window for inserting patients was placed on the lateral side of the re-entrant type applicator with a diameter of 120 cm and height of 120 cm that had been developed for research use. Initially, using three-dimensional computer simulation, we confirmed that electric field leakage to the outside area was below the allowance. We then measured electric field leakage using a phantom. We were able to confirm that the electric field was within the allowance at least 50 … More cm away from the window. This finding was presented at The 19th Annual Meeting of the Japanese Society of Hyperthermic Oncology.Furthermore, a phantom in the shape of a human body was heated, and the distribution of temperature was measured by infrared thermography. When thermotherapy was conducted at 30 W for 15 minutes, the temperature at the core of the phantom increased by 4.5 degrees, while that at the surrounding area was less than 2 degrees, and no problematic hot spot was seen. This finding was presented at The Annual Meeting of Denshi-johotsushin at Shinetsushibu.In an animal study, a beagle was inserted through the round window on the side of the re-entrant type applicator. Electric field leakage was also below the allowance at least 50 cm away from the window.If re-entrant type thermotherapy is applied clinically, thermotherapy can be repeatedly performed in a noninvasive manner, thus increasing the efficacy of thermotherapy. Noninvasive thermotherapy in the head region using a re-entrant type applicator appears to be promising, and it should be clinically useful. Less

为了减少恶性脑肿瘤热疗的侵入性，我们一直在研究使用一种无创加热装置--再入式加热器的加热技术，并于2001年进行了控制加热程度的实验。通过对试验装置进行一些改进，并改变凹入区域的直径，我们能够确认加热的程度可以控制在最大约80%的加热组织。用于插入患者的圆形窗口被放置在该区域的外侧，直径120厘米、高120厘米的入门型施药器已开发用于研究。最初，使用三维计算机模拟，我们确认，电场泄漏到外部区域低于允许值。然后，我们使用体模测量电场泄漏。我们能够确认电场在允许范围内至少50 ...更多信息离窗户一厘米远。在第19届日本肿瘤热疗学会年会上发表了这一发现。此外，对人体形状的体模进行加热，通过红外线热成像仪测量温度分布。当以30 W进行热疗15分钟时，体模核心温度升高4.5度，而周围区域的温度升高小于2度，未观察到有问题的热点。这一发现在Shinetsushibu举行的电子商务年会上发表。在一项动物研究中，将一只比格犬从凹进式施源器侧面的圆窗插入。如果临床应用折返式热疗，可以无创地重复进行热疗，从而提高热疗的疗效。头部区域的非侵入性热疗，使用一个再入型的喷头似乎是有前途的，它应该是临床上有用的。少