IMMUNOLOGICAL ANALYSIS OF THE RATS WITH ANTERIOR HYPOTHALAMIC LESIONS

下丘脑前部病变大鼠的免疫学分析

• 批准号: 02454335
• 负责人: TANAKA Ryuichi
• 金额: $ 4.35万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454335/
• 关键词: Hypothalamus; Neuroimmunomodulation; Lymphocyte subset; Natural killer activity; Immunological memory; Flowcytometry; Rat; hypothalamus; immune response; rat; immunological memory; flow cytometry; lymphocyte subset; natural killer activity

We have previously identified the suppression of the lymphocyte blastogenesis and the acceleration of the growth of the subcutaneous tumors by bilateral anterior hypothalamic lesions in rats. The present study was performed to clarify the changes in the lymphocyte subsets and the NK activity after making the lesions. The influence on the immunological memory was also studied. CD4 to CD8 ration of the peripheral blood lymphocytes and spleen cells. T cell receptor alpha beta positive cells of the thymocytes and NK activity of the spleen cells have decreased significantly. MHC antigen expressions on the RBL-1 cells intraperitoneally injected to the preimmunized rats were also suppressed. These results suggest that the anterior hypothalamus has some influences on the control of the cellularimmunological functions at the peripheral level, on the maturation of T cells at the level of thymus and on the antigen recognition by T cell receptors and MHC antigens.

我们先前在大鼠双侧下丘脑前部损伤中发现了抑制淋巴细胞增殖和促进皮下肿瘤生长的作用。本研究旨在阐明皮损后淋巴细胞亚群和NK活性的变化。并研究了其对免疫记忆的影响。外周血淋巴细胞和脾细胞的CD4/CD8比值。胸腺细胞的T细胞受体α-β阳性细胞和脾细胞的NK活性均明显下降。免疫前大鼠腹腔注射的RBL-1细胞的MHC抗原表达也受到抑制。这些结果表明，下丘脑前部在外周水平对细胞免疫功能的调控、在胸腺水平对T细胞的成熟以及T细胞受体和MHC抗原的识别有一定的影响。

项目成果

森 宏: "ラット前視床下部破壊による各種免疫学的パラメーター変動の解析" 神経免疫研究. 5. (1993)

Hiroshi Mori：“大鼠下丘脑前部破坏导致的各种免疫学参数变化的分析”神经免疫学研究 5。（1993）。

Hiroshi Mori: "The analysis of the changes in the immunological parameters by anterior hypothalamic lesions in rats" Neuroimmunological Research. vol.5.

森浩：“大鼠下丘脑前部病变引起的免疫学参数变化分析”神经免疫学研究。

Hiroshi Mori: "Immunological analysis of the rats with anterior hypothalamic lesions" J Neuroimmunology.

Hiroshi Mori：“下丘脑前部病变大鼠的免疫学分析”J Neuroimmunology。