Intracellular hyperthermia by magnetic submicron particles

磁性亚微米颗粒的细胞内热疗

• 批准号: 62480269
• 负责人: TAZAWA Kenji
• 金额: $ 2.43万
• 依托单位: Toyama Medical & Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480269/
• 关键词: Intracellular hyperthermia; Induction hyperthermia; デキストランマグネタイト; デキストラン・マグネタイト; 強磁性体誘導加温法; 四三酸化鉄誘導加法; Intracellular Hyperthermia; 誘導加温療法; 細胞内ハイパーサーシア; 細胞内誘導加温法; 磁性誘導細胞加温法

We have reported "Active Hyperthermia" by means of inductive baeting using submicron excting perticles. An inductive hyperthermia system at 500KHZ to examine the characteristics of various submicron particles was prepared. At 500KHZ, Fe_3O_4, Fe Iron Metal, SUS 430LAN, 3C and Dextran Magnetite (Fe 207mg and Dextran 84mg/ml) showed good exciting characteristics, while Fe_2O_3 and Mn-Zn ferrite remainde at low exciting temparature. Dextran Magnetite, one of the new exciting particle, at a frequency of 500KHZ were very promising.The injected submicron particles intrapentonally, located interacellularlly in ascitic cells of AH60C by tumor cell phagocytosis. These submicron particles in tumor cells at the field of inductive heating system were excited as same as in vitro. In the experiment of in vivo using 3C and Dextran magnetite, comparing with other groups, were most effective. It is suggested that the selective uptake of the particles by tumor cells is practicable for selective hyperthermia of cancer cells. This biophysical approach represents new thechnology for effective treatment of hyperthermia, resulting in the selective destruction of cancer cells with little side effects on the sorrounding normal cells and tissue.

我们已经报道了通过使用亚微米激发微粒进行感应加热的“主动热疗”。制备了500KHZ的感应热疗系统来检查各种亚微米颗粒的特性。在500KHZ下，Fe_3O_4、Fe铁金属、SUS 430LAN、3C和右旋糖酐磁铁矿（Fe 207mg和右旋糖酐84mg/ml）表现出良好的激发特性，而Fe_2O_3和Mn-Zn铁氧体在较低的激发温度下仍表现出良好的激发特性。右旋糖酐磁铁矿是一种新的令人兴奋的粒子，频率为500KHZ，非常有前途。腹膜内注射的亚微米粒子，通过肿瘤细胞的吞噬作用定位在AH60C腹水细胞的细胞间。肿瘤细胞中的这些亚微米颗粒在感应加热系统场中与体外一样被激发。在体内实验中使用3C和右旋糖酐磁铁矿，与其他组相比，最有效。这表明肿瘤细胞对颗粒的选择性摄取对于癌细胞的选择性热疗是可行的。这种生物物理方法代表了有效治疗高热的新技术，可选择性破坏癌细胞，而对周围的正常细胞和组织几乎没有副作用。

项目成果

TAKEMORI,S;TAZAWA,K;YAMASHITA,I;MAEDA,M;HONDA,T;etal: Japanese Journal of Cancer Research:Proceedings of the Japanese Cancer Association,46th Annual Meeting. 498 (1987)

TAKEMORI,S;Tazawa,K;YAMASHITA,I;MAEDA,M;HONDA,T;etal：日本癌症研究杂志：日本癌症协会会议记录，第 46 届年会。

田沢賢次、竹森繁 他: Japanese Journal of Cancer Research:proceeding of the Japanese Cancer Association. 47. 623 (1988)

Kenji Tazawa、Shigeru Takemori 等人：日本癌症研究杂志：日本癌症协会会议记录 47. 623 (1988)。

TAKEMORI S.; TAZAWA K.; YAMASHITA I. et al: "The quality and characteristic of the material as heat sensitive ferromagnetic implant for the purpose of portable magnetic induction heating" Japanese Journal of Cancer Research :Proceedings of the Japanese Ca

武森 S.；

TAZAWA K.; TAKEMORI S.; YAMASHITA I.; et al: "Intracellular hyperthermia by fixated submicron particle exciting in inductive field of 500KHZ" International Hyperthermic Oncology. (1989)

田泽K.；

TAZAWA K.; TAKEMORI S.; YAMASHITA I.; et al: "Intracellular hyperthermia : Effects of intracellular submicron particles exciting in induction field of 500KHZ" Japanese Journal of Cancer Research :Proceeding of the Japanese Cancer Association. 46. 498 (198

田泽K.；