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Analysis of the mechanism of colonic carcinoma transference depression by apple pectin.

苹果果胶抑制结肠癌转移的机制分析

基本信息

批准号：
06671189
负责人：
TAZAWA Kenji
金额：
$ 1.34万
依托单位：
TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

As for apple pectin, it is known that outbreak of carcinoma of colon is prevented by giving influence to intestinal flora. Apple pectin has had strong bacteriostasis for intestinal flora of disease-causing germs. And apple pectin lets intestine endoenzyme (beta-glucuronidase) activity fall by letting weak acid change pH in intestine. It was reported in the 53rd annual meeting of Japanese Cancer Association about an above-mentioned point. In 1995, the influence that apple pectin gave to bile acid concentration and bile acid metabolism during feces was examined, and the next result was got. Bile acid concentration was measured during feces of rats after having administered AOM for 24 weeks. As for apple pectin group, tendency to decrease of quantity of general bile acid was watched than control group, and, in particular, primary bile acid dose has done decrement in significance. And, metabolism of cholic acid which was primary bile acid, defluxion dose to urine and feces was examined usi … More ng the 14C label body. In apple pectin group, defluxion to urine and feces of cholic acid did decrease after 24 hours, and radioactivity concentration in blood has accumulated it in hepar and kidney much highly even in after 48 hours. In other words, it was supposed that there was more rate of enterohepatic circulation of cholic acid in apple pectin group. In examination of this time, decrement of gain of enterohepatic circulation of bile acid by the apple pectin dosage and defluxion to the feces inside was suggested. Besides decrement of primary bile acid concentration in feces was recognized. It was thought as the cause that these consequence restrained large bowel carcinogenesis. It will need to be examined in bile acid metabolism of other modality in future whether equal consequence is been. About these, it was announced in the 7th Japan digestive organ canceration meeting. On the other hand, dietary fiber has participated in auxesis and action maintenance of alimentary canal epithelium, and, in late years, it has become clear that pectin is important in immunology amelioration of intestine epithelium. Apple pectin lets prostaglandin EZ value in intestine tunica mucosa ventriculi and portal vein fall and depression of liver metastasis of AH60C rat model is high. We reported this consequence in the 54th annual meeting of Japanese Cancer Association for the first time in the world. Carcinoma transference depression by such dietary fiber has affected gut immunity augmentation deep. It is convinced that it contributes to analysis of mechanism of autotherapy of carcinoma and resolution of carcinoma palindromia greatly to make clear mechanism of carcinoma transference depression. Less

关于苹果果胶，已知通过影响肠道植物群来防止结肠癌的发生。苹果果胶对肠道致病菌植物群有较强的抑菌作用。苹果果胶通过使肠道内弱酸改变pH值，使肠道内酶（β-葡萄糖醛酸酶）活性下降。在日本癌症协会第53届年会上报告了上述观点。1995年，研究了苹果果胶对粪便中胆汁酸浓度和胆汁酸代谢的影响，得到了下一个结果。给药AOM 24周后，在大鼠粪便中测定胆汁酸浓度。苹果果胶组总胆汁酸量较对照组有下降趋势，尤其是初级胆汁酸量有显著下降。同时，用放射免疫法测定了大鼠胆汁酸代谢，尿、粪排出量， ...更多信息 ng 14 C标记体。苹果果胶组24小时后胆汁酸流出尿、粪的量减少，血中放射性浓度在肝、肾中蓄积较高，48小时后仍有增加。因此，推测苹果果胶组胆酸的肠肝循环率较高。在这一时间的检查中，建议苹果果胶剂量减少胆汁酸肠肝循环的获得并流出到粪便中。此外，粪便中的初级胆汁酸浓度降低。这些结果被认为是抑制大肠癌发生的原因。将来需要检查其他形式的胆汁酸代谢是否具有相同的结果。关于这些，在第七届日本消化器官癌变会议上公布。另一方面，膳食纤维参与了消化道上皮细胞的生长和功能维持，近年来，果胶在肠上皮细胞的免疫改善中的重要性已变得清楚。苹果果胶可使AH 60 C大鼠模型肠图尼卡膜、胃粘膜、门静脉前列腺素EZ值下降，对肝转移的抑制作用高。我们在日本癌症协会第54届年会上首次报道了这一结果。这种膳食纤维抑制癌转移对肠道免疫增强有很深的影响。明确肿瘤转移抑制的机制，对于分析肿瘤自身治疗的机制，解决肿瘤复发具有重要意义。少