Analysis of the mechanism of colonic carcinoma transference depression by apple pectin.

至于苹果果胶，我们知道它可以通过影响肠道菌群来预防结肠癌的爆发。苹果果胶对肠道致病菌有很强的抑菌作用。苹果果胶通过让弱酸改变肠道的pH值来降低肠道内酶（β -葡萄糖醛酸酶）的活性。在第53届日本癌症协会年会上，有关于上述观点的报道。1995年，研究了苹果果胶对粪便中胆汁酸浓度和胆汁酸代谢的影响。给药24周后测定大鼠粪便中胆汁酸浓度。苹果果胶组大鼠总胆汁酸含量较对照组有下降趋势，尤其是初级胆汁酸剂量有显著下降。用14C标记体测定了原胆汁酸胆酸的代谢、排尿剂量和粪便排泄量。苹果果胶组在24小时后，胆酸排入尿液和粪便的量明显减少，在48小时后，血液中的放射性浓度仍在肝和肾中积聚。也就是说，苹果果胶组胆酸的肠肝循环速率更高。在这次的检查中，建议苹果果胶用量减少胆汁酸肠肝循环的增加，并将其排入粪便中。此外，粪便中原发性胆汁酸浓度下降。这些结果被认为是抑制大肠癌发生的原因。今后在其他方式的胆汁酸代谢中是否有同样的结果需要进一步研究。关于这些，是在第七届日本消化器官癌变会议上公布的。另一方面，膳食纤维参与了消化道上皮的补充和作用维持，近年来人们逐渐认识到果胶在肠上皮免疫改善中的重要作用。苹果果胶使AH60C模型大鼠肠粘膜、脑室、门静脉前列腺素EZ值下降，对肝转移抑制作用高。我们在世界上首次在第54届日本癌症协会年会上报道了这一结果。抑制癌转移的膳食纤维对肠道免疫的增强有很深的影响。明确肿瘤转移抑制的机制，有助于分析肿瘤的自愈机制和肿瘤复发的解决。少

As for apple pectin, it is known that outbreak of carcinoma of colon is prevented by giving influence to intestinal flora. Apple pectin has had strong bacteriostasis for intestinal flora of disease-causing germs. And apple pectin lets intestine endoenzyme (beta-glucuronidase) activity fall by letting weak acid change pH in intestine. It was reported in the 53rd annual meeting of Japanese Cancer Association about an above-mentioned point. In 1995, the influence that apple pectin gave to bile acid concentration and bile acid metabolism during feces was examined, and the next result was got. Bile acid concentration was measured during feces of rats after having administered AOM for 24 weeks. As for apple pectin group, tendency to decrease of quantity of general bile acid was watched than control group, and, in particular, primary bile acid dose has done decrement in significance. And, metabolism of cholic acid which was primary bile acid, defluxion dose to urine and feces was examined usi … More ng the 14C label body. In apple pectin group, defluxion to urine and feces of cholic acid did decrease after 24 hours, and radioactivity concentration in blood has accumulated it in hepar and kidney much highly even in after 48 hours. In other words, it was supposed that there was more rate of enterohepatic circulation of cholic acid in apple pectin group. In examination of this time, decrement of gain of enterohepatic circulation of bile acid by the apple pectin dosage and defluxion to the feces inside was suggested. Besides decrement of primary bile acid concentration in feces was recognized. It was thought as the cause that these consequence restrained large bowel carcinogenesis. It will need to be examined in bile acid metabolism of other modality in future whether equal consequence is been. About these, it was announced in the 7th Japan digestive organ canceration meeting. On the other hand, dietary fiber has participated in auxesis and action maintenance of alimentary canal epithelium, and, in late years, it has become clear that pectin is important in immunology amelioration of intestine epithelium. Apple pectin lets prostaglandin EZ value in intestine tunica mucosa ventriculi and portal vein fall and depression of liver metastasis of AH60C rat model is high. We reported this consequence in the 54th annual meeting of Japanese Cancer Association for the first time in the world. Carcinoma transference depression by such dietary fiber has affected gut immunity augmentation deep. It is convinced that it contributes to analysis of mechanism of autotherapy of carcinoma and resolution of carcinoma palindromia greatly to make clear mechanism of carcinoma transference depression. Less